This book constitutes the refereed proceedings of the 12th International Conference on Security, Privacy, and Applied Cryptography Engineering, SPACE 2022 held in Jaipur, India, during December 9–12, 2022.The 18 full papers included in this book were carefully reviewed and selected from 61 submissions.

​Symmetric Cryptography.- Modeling Large S-box in MILP and a (Related-key) Differential Attack on Full Round PIPO-64/128.- Light but Tight: Lightweight Composition of Serialized S-Boxes with Diffusion Layers for Strong Ciphers.- Hardware Implementation of Masked SKINNY SBox with Application to AEAD.- Bias Cancellation of MixColumns.- Big Brother Is Watching You: A Closer Look At Backdoor Construction.- Public-key Cryptography, Post-quantum Cryptography, Zero Knowledge Proofs.- KEMTLS vs. Post-Quantum TLS: Performance on Embedded Systems.- Protecting the most significant bits in scalar multiplication algorithms.- Combining Montgomery Multiplication with Tag Tracing for the Pollard ' s Rho Algorithm in Prime Order Fields.- Card-based zero-knowledge proof for the nearest neighbor property: Zero-knowledge proof of ABC end view.- Hardware Security and AI.- What Do You See? Transforming Fault Injection Target Characterizations.- Dual-Tone Multi-Frequency Assisted Acoustic Side Channel Attack to Retrieve Dialled Call Log.- Machine Learning Attacks on Low-Cost Reconfigurable XRRO and XRBR PUF Designs.- HWGN2: Side-channel Protected NNs through Secure and Private Function Evaluation.- How Many Cameras Do You Need? Adversarial Attacks and Countermeasures for Robust Perception in Autonomous Vehicles.- Network security, Authentication, and Privacy.- SMarT: A SMT based Privacy Preserving Smart Meter Streaming Methodology.- An analysis of the hardware-friendliness of AMQ data structures for network security.- RemOD: Operational Drift-adaptive Intrusion Detection.- A short note on a paper titled A Delaunay Quadrangle-Based Fingerprint Authentication System with Template Protection using Topology Code for local registration and security enhancement.