This two-volume set constitutes selected papers presented during the First First International Conference on Science, Engineering Management and Information Technology, SEMIT 2022, held virtually in Ankara, Turkey, in February 2–3, 2022 and in September 8-9, 2022. The 37 papers presented were carefully reviewed and selected from the 261 qualified submissions. The papers are organized in the following topical sections: application of computer science and technology in operations and supply chain management; advances of engineering technology and Artificial Intelligence in application management; technology-aided decision-making: systems, applications, and modern solutions.