This book constitutes the refereed proceedings of the 11th International Conference on Model and Data Engineering, MEDI 2022, held in Cairo, Egypt, in November 2022. The 18 full papers presented in this book were carefully reviewed and selected from 65 submissions. The papers cover topics such as database systems, data stream analysis, knowledge-graphs, machine learning, model-driven engineering, image processing, diagnosis, natural language processing, optimization, and advanced applications such as the internet of things and healthcare.