This symposium was born as a research forum to present and discuss original, rigorous and significant contributions on Artificial Intelligence-based (AI) solutions—with a strong, practical logic and, preferably, with empirical applications—developed to aid the management of organizations in multiple areas, activities, processes and problem-solving; what we call Management Intelligent Systems (MiS). This volume presents the proceedings of these activities in a collection of contributions with many original approaches. They address diverse Management and Business areas of application such as decision support, segmentation of markets, CRM, product design, service personalization, organizational design, e-commerce, credit scoring, workplace integration, innovation management, business database analysis, workflow management, location of stores, etc. A wide variety of AI techniques have been applied to these areas such as multi-objective optimization and evolutionary algorithms, classification algorithms, ant algorithms, fuzzy rule-based systems, intelligent agents, Web mining, neural networks, Bayesian models, data warehousing, rough sets, etc. This volume also includes a track focused on the latest research on Intelligent Systems and Technology Enhanced Learning (iTEL), as well as its impacts for learners and institutions. It aims at bringing together researchers and developers from both the professional and the academic realms to present, discuss and debate the latest advances on intelligent systems and technology-enhanced learning The symposium was organized by the Soft Computing and Intelligent Information Systems Research Group(http://sci2s.ugr.es) of the University of Granada (Spain) and the Bioinformatics, Intelligent System and Educational Technology Research Group (http:// bisite.usal.es/) of the University of Salamanca (Spain). The present edition was held in Salamanca (Spain) on May 22–24, 2013.