The ISoLA 2024 proceedings constitutes contributions of the associated events held at the 12th International Symposium on Leveraging Applications of Formal Methods, ISoLA 2024, which took place in Crete, Greece, in October 2024.

Digital Twin Engineering (Track Introduction ISoLA 2024).- Foundation Models for the Digital Twins Creation of Cyber-Physical Systems.- Interoperability of Digital Twins: Challenges, Success Factors, and Future Research Directions.- Monitoring Reconfigurable Simulation Scenarios in Co-simulated Digital Twins.- DiTEC: Digital Twin for Evolutionary Changes in Water Distribution Networks.- Small Scale, Big Impact: Experiences from a Miniature ViL Testbed and Digital Twin Development.- Formal methods for distributed computing in future railway systems.- Model-based Testing of Railway Interlocking Systems.- Formal Verification of Railway Interlockings: a Compositional Approach Based on a Library of Pre-Verified Components.- Formal Validation and ERTMS Simulation.- Securing automatic small railway vehicles using Automatic Train Protection.- Railway Switch Control Modeling in European Train Control System Level 3.- An Integrated Perspective on the Evaluation of Complex Railway Systems.