This book, the third volume of Information Systems Research in Vietnam, presents a special theme that focuses on two emerging and critical topics of the twenty-first century: “Digital Transformation” and “Sustainable Development”. Digital transformation, which consists of digitization of products and digitalization of work processes, has brought forth exciting new business models that disrupt traditional industries. Digital transformation has been embedded in the 2030 National Digital Transformation Programme of the Vietnamese government, leading to numerous digital businesses that offer significant value in various sectors, including retail, manufacturing, education, and health care. Partly due to the United Nations (UN) 17 Sustainable Development Goals (SDGs) specifying the key development areas and outlining collective actions to ensure continuing peace and prosperity for people and the planet, organizations in Vietnam are becoming increasingly aware of the importance of sustainable development and the adoption of sustainability governance frameworks such as ESG to gain strategic advantages in the turbulent markets. Information systems (IS), in particular, has profound impacts on achieving Sustainable Development. However, best practices and case studies about Digital Transformation and how this transformation and IS applications influence Sustainable Development in Vietnam have not been documented and studied, in spite of the rapid developments in these areas in both public and private sectors. This book, therefore, contributes to the existing body of knowledge and benefits a wide range of readers in several ways. Firstly, the book benefits scholars and students, both in Vietnam and globally, by advancing knowledge and presenting research on the latest trends in contemporary topics such as Digital Transformation and Sustainable Development, especially in the under-researched Vietnam context. Secondly, industry practitioners and experts, both in Vietnam and globally, will benefit from reading this book to keep up with the current trends, case studies, and applications. Thirdly, by presenting the most up to date knowledge on the topic, this book creates a shared understanding to help facilitate future research in the IS field, as well as providing the background to pave the way for collaboration between scholars, experts, and industry practitioners.