This book constitutes the thoroughly refereed proceedings of the 12th International Conference on Evaluation of Novel Approaches to Software Engineering, ENASE 2017, held in Porto, Portugal, in April 2017.The 12 full papers presented were carefully reviewed and selected from 102 submissions.

Service Science and Business Information Systems.- Guidelines for Designing User Interfaces to Analyze Genetic Data. Case of Study: GenDomus.- Biologically Inspired Anomaly Detection Framework.- Genomic Tools*: Web-applications based on Conceptual Models for the Genomic Diagnosis.- Technological Platform for the Prevention and Management of Healthcare Associated Infections and Outbreaks.- Software Engineering.- Exploiting Requirements Engineering to Resolve Conflicts in Pervasive Computing Systems.- Assisting Configurations-based Feature Model Composition - Union, Intersection and Approximate Intersection.- A Cloud-based Service for the Visualization and Monitoring of Factories.- An Operational Semantics of UML2.X Sequence Diagrams for Distributed Systems.- Fast Prototyping of Web-based Information Systems using a Restricted Natural Language Specification.- Model-based Analysis of Temporal Properties.- Towards a Java Library to Support Runtime Metaprogramming.- Design Approaches for Critical Embedded Systems: A Systematic Mapping Study.