This book constitutes the refereed proceedings of the 22nd International Conference on Parallel and Distributed Computing, Euro-Par 2016, held in Grenoble, France, in August 2016. The 47 revised full papers presented together with 2 invited papers and one industrial paper were carefully reviewed and selected from 176 submissions. The papers are organized in 12 topical sections: Support Tools and Environments; Performance and Power Modeling, Prediction and Evaluation; Scheduling and Load Balancing; High Performance Architectures and Compilers; Parallel and Distributed Data Management and Analytics; Cluster and Cloud Computing; Distributed Systems and Algorithms; Parallel and Distributed Programming, Interfaces, Languages; Multicore and Manycore Parallelism; Theory and Algorithms for Parallel Computation and Networking; Parallel Numerical Methods and Applications; Accelerator Computing.