This book constitutes the refereed proceedings of the Second Southern African Conference on  Artificial Intelligence Research, SACAIR 2021, held in Durban, South Africa, in  December 2021. Due to the COVID-19 pandemic the SACAIR 2021 was held online. The 22 papers presented were thoroughly reviewed and selected from the 70 submissions. They are organized on the topical sections on ​AI in the humanities and society, AI in and for information systems, computer vision and image processing, deep learning, knowledge representation and reasoning, machine learning, philosophy and ethics of AI.