This book presents the latest research on Ambient Intelligence (AmI) including software and applications in different areas such as Internet of Things, Multi-Agent Systems or e-Learning, among others. AmI is a paradigm emerging from Artificial Intelligence, in which computers are used as proactive tools for assisting people with their day-to-day activities, making everyone’s lives more comfortable. Another main concern of AmI originates from the human–computer interaction domain and focuses on offering ways to interact with systems in a more natural way by means of user-friendly interfaces. The published book correspond to technical and novel works carried out by scientists conducting research within the AmI area in one of the areas mentioned above. The intended readers are those with mainly technical profiles who are already working in the area of AmI or who want to focus their current work in this area.The papers collected in this book were presented at a symposium which was jointly organized by the Universidade do Minho and University of Salamanca. The latest installment was held in Salamanca, Spain, from October 6th to 8th, 2021. The authors wish to thank the sponsors: IBM, Indra, Viewnext, Global Exchange, AEPIA, APPIA and AIR Institute.