This book constitutes the proceedings of the 16th International Conference on Practical Applications of Agents and Multi-Agent Systems, PAAMS 2018, held in Toledo, Spain, in June 2018. They deal with the application and validation of agent-based models, methods, and technologies in a number of key applications areas, such as: energy and security;

Hammer or Tongs: How Best to Build Agent-Based Models.- Towards Autonomous AI Systems for Resource Management: Applications in Industry and Lessons Learned.- A Holonic Multi-Agent Based Diagnostic Decision Support System for Computer-Aided History and Physical Examination.- A Resilient Agent-Based Re-Organizing Traffic Network for Urban Evacuations.- Coping with Bad Agent Interaction Protocols when Monitoring Partially Observable Multiagent Systems.- SimFI: a Transmission Agent-Based Model of Two Interacting Pathogens.- Electric vehicles  fleet for frequency regulation using multi-agent system.- Using Run-Time Biofeedback during Virtual Agent-Based Aggression De-escalation Training.- Multi-Agent Systems and Blockchain: Results from a Systematic Literature Review.- A Model and Platform for Building Agent-Based Pervasive Mixed Reality Systems.- Classification of Spatio-temporal Trajectories based on Support Vector Machines.- A Cooperative Multi-Agent System for Wind Power Forecasting.- Cooperative agents for discovering Pareto-optimal classifiers under dynamic costs.- Unemployment expectations in an agent-based model with education.- Towards reducing complexity of multi-agent simulations by applying model-driven techniques.- Environment for identification of significant subjects on information portals.- Evaluation of Multi-Agent Coordination on Embedded Systems.- AgentUDE17: A Genetic Algorithm to Optimize the Parameters of an Electricity Tariff in a Smart Grid Environment.- A first step towards a general-purpose distributed cyberdefense system.- A Network-Oriented Adaptive Agent Model for Learning Regulation of a Highly Sensitive Person’s Response.- SAIL: a Social Artificial Intelligence Layer for Human-Machine Teaming.- Agent-Based Model of Smart Social Networking-Driven Recommendations System for Internet of Vehicles.- MAXIM-GPRT: A Simulator of local Schedulers, Negotiations, and Communication for Multi-Agent Systems in General-Purpose and Real-Time Scenarios. -Managing Bad AIPs with RIVERtools.- Developing Agent-Based Pervasive Mixed Reality Systems: the MiRAgE Framework.- Generating unemployment expectations of the "man in the street".- MASAP: Multi-Agent Simulation of Air Pollution.- Analysis of Agent-Based Parallelism for Use in Clustering and Classification Applications.- HVUAN – A rapid-development framework for Spanish-speaking virtual humans.- ATHOS - A domain-specific language for multi-agent simulations.- MASEV: A MAS for the Analysis of Electric Vehicle Charging Stations Location.- On the way of protecting MANETs against security threats: a proactive approach.- Coordinated UAV Search and Rescue Application with JaCaMo.- AgentOil: a multi-agent-based simulation of the drilling process in oilfields.- A social robot assisting in cognitive stimulation therapy.- Swarm of Satellites: Multi-Agent Mission Scheduler for Constellation of Earth Remote Sensing Satellites.- Demonstration of Tools Control Center for Multi-Agent Energy SystemsSimulation.- MATISSE 3.0: A Large-Scale Multi-Agent Simulation System for Intelligent Transportation Systems.- The SAIL Framework for Implementing Human-Machine Teaming Concepts.- A novel web services infrastructure leveraging agent oriented middleware environment for realizing agent oriented information system models.- A Demonstration of Simulation Modeling for SIoV Recommendations System.

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