PAAMS, the International Conference on Practical Applications of Agents and Multi-Agent Systems is the international yearly tribune to present, to discuss, and to disseminate the latest developments and the most important outcomes related to real-world applications. It provides a unique opportunity to bring multi-disciplinary experts, academics and practitioners together to exchange their experience in the development of Agents and Multi-Agent Systems.  This volume presents the papers that have been accepted for the 2011 edition. These articles capture the most innovative results and this year’s trends: Finance and Trading, Information Systems and Organisations, Leisure Culture and Interactions, Medicine and Cloud Computing, Platforms and Adaptation, Robotics and Manufacturing, Security and Privacy, Transports and Optimisation paper.