This book presents a remarkable collection of chapters that cover a wide range of topics in the areas of information and communication technologies and their real-world applications. It gathers the Proceedings of the Future of Information and Communication Conference 2019 (FICC 2019), held in San Francisco, USA from March 14 to 15, 2019. The conference attracted a total of 462 submissions from pioneering researchers, scientists, industrial engineers, and students from all around the world. Following a double-blind peer review process, 160 submissions (including 15 poster papers) were ultimately selected for inclusion in these proceedings. The papers highlight relevant trends in, and the latest research on: Communication, Data Science, Ambient Intelligence, Networking, Computing, Security, and the Internet of Things. Further, they address all aspects of Information Science and communication technologies, from classical to intelligent, and both the theory and applications of thelatest technologies and methodologies. Gathering chapters that discuss state-of-the-art intelligent methods and techniques for solving real-world problems, along with future research directions, the book represents both an interesting read and a valuable asset.