This two-volume set (CCIS 905 and CCIS 906) constitutes the refereed proceedings of the Second International Conference on Advances in Computing and Data Sciences, ICACDS 2018, held in Dehradun, India, in April 2018.The 110 full papers were carefully reviewed and selected from 598 submissions. The papers are centered around topics like advanced computing, data sciences, distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations.