ContributorsPreface 1. 3-Mercaptopyruvate sulfurtransferase: the molecular and functional propertiesNoriyuki Nagahara and Takaaki Ito Adaptation of living organisms to oxidative and chemical environments Molecular evolution of sulfurtransferases MST and evolutionarily related enzymes of TST Molecular, kinetic, and functional properties of MSTProperties of the promoter region of the MST geneMultiple functions of MST related to catalysisPossible production mechanism of H2S and polysulfide from MSTLocalization of MST in rat and mouseMST expression in mouse developmental stagesMST-knockout mouseFuture perspectiveAcknowledgmentsReferencesFurther reading 2. 3-Mercaptopyruvate sulfurtransferase: a review of past and present perspectivesY. Ogasawara Discovery and earlier characterization of 3-MSTComparison of 3-MST with thiosulfate sulfur transferase (rodanase)Purification and catalytic reactionAmino acid sequence and protein structurePhysiological role of 3-MST3-MST and rhodanese in selenium metabolismMethods for measuring 3-MP and 3-MST activitiesClinical studies on 3-MST and the construction of 3-MST knockout miceLocalization and significance of 3-MST in the central nervous systemInvolvement of 3-MST in sulfane sulfur (bound sulfur) generationReferences 3. The tales of fungal sulfurtransferases: lost, found, and stolenSebastian Piłsyk References 4. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide (H2S), polysulfides (H2Sn), and other S-sulfurated signaling moleculesHideo Kimura Introduction3MST produces H2S H2S and H2Sn regulate neuronal transmission 3MST as H2Sn producing enzyme Signaling via S-sulfuration of target proteins Energy formation versus its suppression by H2S Cytoprotection against oxidative stressInvolvement of 3MST and H2S in the pathogenesis of schizophreniaPerspectivesReferences 5. A persulfide shield: an endogenous reactive sulfur species in the forefront in the electrophile detoxification pathwayHisyam Abdul Hamid, Tsuyoshi Takata, Tetsuro Matsunaga and Takaaki Akaike IntroductionBiosynthesis of biological polysulfidesA “persulfide shield”: proposed as an electrophile defense mechanismRSS versus heavy metalsRSS versus alkylating agents and xenobioticsFuture directions of RSS-based researchAcknowledgmentReferences 6. Thiosulfate sulfurtransferase: a model of essential enzyme with potential applications in medicine and biotechnologySilvia Buonvino, Giulia Cinotti and Sonia Melino IntroductionTST/rhodanese structure: a model for studying the protein foldingTST in the cell metabolismDiseases related to TST dysregulationTST in biotechnologyReferencesFurther reading 7. Chemical approaches to discover selective inhibitors of sulfurtransferases and transsulfuration enzymesEita Sasaki and Kenjiro Hanaoka IntroductionWidely used inhibitors of CBS, CSE, 3MST, and rhodaneseChemical approaches to discover new inhibitorsConclusionsReferences 8. New insight into the role of TST-derived hydrogen sulfide, a key regulator of mesenteric homeostasis, in health and during chronic fructose intakeOleh Revenko, Yaroslav Pavlovsky, Iryna Kovalchuk, Maryana Savytska and Oksana Zayachkivska IntroductionThe beneficial role of TST-derived hydrogen sulfideSummaryReferencesFurther reading 9. The S-adenosyl-L-methionine radical enzymes: the lipoic acid synthase and the biotin synthaseAnna Bilska-Wilkosz Metabolic role of lipoic acidBiosynthesis of lipoic acidMetabolic role of biotinThe biosynthetic pathway of biotinRadical S-adenosyl-L-methionine superfamily of enzymesThe lipoyl synthaseThe biotin synthaseReferences 10. Sulfur transferases in the pathways of molybdenum cofactor biosynthesis and tRNA thiolation in humansSilke Leimkühler and Moses Olalekan Ogunkola IntroductionThiolation of tRNAThiocarboxylate formation on the URM1 proteinMoco biosynthesisMOCS3NFS1TUM1MTU1CTU1ConclusionsReferencesIndex

Brings together basic knowledge and applied research across a wide range of sulfurtransferases Considers biochemical functioning, enzymatic regulation and activity, and related pathologies for each enzyme Features chapter contributions from global leaders in the field