Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types.
Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application.
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Part 1: Introduction
1. Mitochondrial Transplantation: Methods and Mitochondrial Dysfunction Diseases: An Overview
2. Mitochondria and Cell Metabolism
3. Mitochondrial Dynamics and Mitochondrial Biogenesis
4. Mitochondrial DNA and Heteroplasmy
Part 2: Physiological Mitochondrial Transfer
5. Tunnelling Nano Tube (TNT)
6. Microvesicles and Gap Junctions
Part 3: Mitochondrial Transplantation from Isolation Process to Application
7. Isolation Process for Mitochondrial Transplantation
8. Determination of Mitochondrial Number and Function
9. Storage of Isolated Mitochondria10. Mitochondrial Transplantation Methods
11. Application Route of Mitochondrial Transplantation
12. Limitations of Mitochondrial Transplantation
13. Ethical Issues about Mitochondrial Transplantation
Part 4: Cardiovascular Diseases and Mitochondrial Transplantation
14. Cardiovascular Diseases and Pathophysiology
15. Pre-clinical Studies
16. Clinical Studies
Part 5: Neurological Diseases and Mitochondrial Transplantation
17. Neurological Diseases and Pathophysiology
18. Pre-clinical Studies
Part 6: Other Diseases and Mitochondrial Transplantation
19. Hereditary Mitochondrial Diseases and Mitochondrial Transplantation
20. Kidney Injury and Mitochondrial Transplantation
21. Cancer and Mitochondrial Transplantation
22. Diabetes and Mitochondrial Transplantation
24. Aging and Mitochondrial Transplantation
25. Future Aspects of Mitochondrial Transplantation
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An in-depth but accessible treatment of mitochondrial transplantation and transfer, considering fundamental biology, methods, and applications
Provides an in-depth discussion of mitochondrial transplantation, considering fundamental biology, disease implications, research methods and applications
Discusses recent advances in the field and their meaning for future research and clinical utility
Considers ethical dimensions of mitochondrial transplantation research and use in therapeutics
Examines mitochondrial transplantation across a range of disease types, from neurological to cardiovascular disease and ischemia
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Produktdetaljer
ISBN
9780443188589
Publisert
2024-08-06
Utgiver
Vendor
Academic Press Inc
Vekt
1160 gr
Høyde
235 mm
Bredde
191 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
560
Redaktør