This book is a collection of contributions presented at the 16th annual international symposium “Frontiers of Fundamental Physics” (FFP16), supported by Istanbul University. As a document of the latest occurrence of this very important gathering, it presents the most recent advances in fundamental physics and physics teaching. For nearly fifteen years, the FFP has attracted some of the greatest physicists in the world. The broad objective of the entire endeavor has been to enable scholars working in slightly different areas to meet on a single platform. Even with this particular year’s safety restrictions arising from Covid, we feel that the general mission has been carried out as fully as in any year. The book features addresses given by a host of expert contributors, all of which are organized according to seven individual themes. The areas covered include Astronomy and Astrophysics, Particle Physics, Theoretical Physics, Gravitation and Cosmology, Computational Physics, Condensed Matter Physics, Complex Systems and related areas. This book should prove to be a veritable bounty for anyone with an interest in the continued evolution of our understanding of the physical world.