1 • Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System.- 2 • Multipotent Stem Cells in the Embryonic Nervous System.- 3 • Multipotent Stem Cells in the Adult Central Nervous System.- 4 • Glial Characteristics of Adult Subventricular Zone Stem Cells.- 5 • Neuronal Restricted Precursors.- 6 • Glial Restricted Precursors.- 7 • PNS Precursor Cells.- 8 • Neural Progenitor Cells of the Adult Human Brain.- 9 • ES Cells and Neurogenesis.- 10 • Mobilizing Endogenous Stem Cells.- 11 • Transplant Therapy.- 12 • Drug Discovery and Gene Discovery.- Appendix A: Neural Stem Cell Companies.- Appendix B: Stem Cells and Transplants.- Appendix C: Patents and Stem Cells.- Appendix D: Stem Cells and US Federal Guidelines.- About the Authors.

Stem cells were recently cited by Science magazine as the scientific breakthrough of the year because of their potential to revolutionize our understanding of the complexities of biological development. In Stem Cells and CNS Development, world renowned authorities in neural stem biology critically review the rapidly emerging findings on this critical class of stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. The authors define by consensus the classes of stem cells in the nervous system, compare their similarities and differences, discuss the gains made in identifying human homologs of neural stem cells, and describe how these cells are beginning to be used for therapeutic purposes. Their examination includes all the major issues in stem cell biology, save apoptosis and cell cycle regulators. Comprehensive and cutting-edge, Stem Cells and CNS Development provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.

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