This book presents the latest knowledge, trends, and advances in cell
transplantation and innovations in developing microspheres, 3D
biomaterial constructs to enhance transfer, and cell survival to
specific regions of the brain. Neurodegenerative diseases and brain
injury are increasing. Medications currently only temporarily reduce
some of the symptoms but do not cure or delay progression of the
disease. Development of effective treatments dramatically improves the
independent living and quality of life of patients. Cell
transplantation strategies offer an approach to facilitating brain
repair, but efficacy is often limited by low in vivo survival rates of
cells that are injected in suspension. Transplanting cells that are
attached to or encapsulated within a biomaterial construct has the
advantage of maintaining cell-cell and cell-material interactions and
improving cell survival in vivo. Biomaterials that have been used in
preclinical studies to assist with in vivo cell transfer and survival
include heparin-chitosan microspheres, poly(lactic-co-glycolic acid)
microspheres, RADA 16 microspheres, poly(desaminotyrosyl tyrosine
ethyl ester carbonate) microscale scaffolds, carbon nanotubes,
collagen-chitosan scaffolds, poly(L-lactic acid) scaffolds, agarose
hydrogels, gelatin methacrylate hydrogels, and agarose micro-columns
with an extracellular matrix interior. Incorporating growth factors
(e.g., glial-derived neurotrophic factor, neurotrophin 3) into the
biomaterial constructs increased cell survival and incorporation into
the host tissue. International experts in the fields of both
experimental and clinical neurological research contribute chapters to
this book and discuss the latest achievements in cell transplantation
and matrix-assisted cell transfer/survival technologies for diseases
such as Alzheimer’s disease, Parkinson’s disease, and brain
injuries such as stroke and traumatic brain injury. It is envisaged
that research findings in experimental animal models of Alzheimer’s
disease, Parkinson’s disease, traumatic brain injury, and stroke
promote clinical trials using biomaterial-assisted transfer of cells.
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Produktdetaljer
ISBN
9783031497445
Publisert
2024
Utgiver
Vendor
Springer
Språk
Product language
Engelsk
Format
Product format
Digital bok