Section I: TARGETTING AD 1. Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings Kaj Blennow and Henrik Zetterberg 2. Tracking down a missing trigger for Alzheimer's disease by mass spectrometric imaging based on brain network analysis Minako Hoshi 3. Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid β-protein Ariel J. Kuhn and Jevgenij A. Raskatov Section II: ETIOLOGY OF AD 4. In search of pathogenic amyloid β-peptide in familial Alzheimer's disease Michael S. Wolfe 5. Biology of splicing in Alzheimer's disease research Kenichi Nagata, Takashi Saito, Takaomi C. Saido and Takashi Morihara 6. Acquired cerebral amyloid angiopathy: An emerging concept Masahito Yamada, Tsuyoshi Hamaguchi and Kenji Sakai Section III: NEUROIMMUNOLOGY OF AD 7. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease Goran Šimić, Ena Španić, Lea Langer Horvat and Patrick R. Hof 8. Gut microbiota mediated allostasis prevents stress-induced neuroinflammatory risk factors of Alzheimer's disease Susan Westfall, Umar Iqbal, Maria Sebastian and Giulio Maria Pasinetti 9. Neuroimmune interactions in Alzheimer’s disease—New frontier with old challenges? Stefan Prokop, Virginia M.Y. Lee and John Q. Trojanowski Section IV: AD THERAPY 10. Alzheimer's therapy development: A few points to consider Einar M. Sigurdsson 11. The next steps in curing Alzheimer's disease Fred W. van Leeuwen 12. Future horizons in Alzheimer's disease research Thomas Wisniewski and Eleanor Drummond 13. Why delay in effective treatment for Alzheimer's disease and related conditions Khalid Iqbal, Fei Liu, ChengXin Gong, Chunling Dai and Wen Hu 14. Restoring synaptic function through multimodal therapeutics Raul Loera-Valencia, Muhammad-Al-Mustafa Ismail, Per Nilsson and Bengt Winblad 15. Disease-modifying therapy for proteinopathies: Can the exception become the rule? Gal Bitan 16. Combination therapy for Alzheimer’s disease and related dementias Martin M. Bednar Section V: ALPHA-SYNUCLEINOPATHIES 17. Can infections trigger alpha-synucleinopathies? Christopher T. Tulisiak, Gabriela Mercado, Wouter Peelaerts, Lena Brundin and Patrik Brundin 18. Prion-like propagation of α-synuclein in neurodegenerative diseases Airi Tarutani and Masato Hasegawa Section VI: MODEL SYSTEMS 19. Yeast models of neurodegenerative diseases Mick F. Tuite

Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field