The book aims to face the challenge of post-COVID-19 dynamics toward green and digital transition, between metropolitan and return to villages’ perspectives. It presents a multi-disciplinary scientific debate on the new frontiers of strategic and spatial planning, economic programs and decision support tools, within the urban–rural areas networks and the metropolitan cities. The book focuses on six topics: inner and marginalized areas local development to re-balance territorial inequalities; knowledge and innovation ecosystem for urban regeneration and resilience; metropolitan cities and territorial dynamics; rules, governance, economy, society; green buildings, post-carbon city and ecosystem services; infrastructures and spatial information systems; cultural heritage: conservation, enhancement and management. In addition, the book hosts a Special Section: Rhegion United Nations 2020-2030. The book will benefit all researchers, practitioners and policymakers interested in the issues applied to metropolitan cities and marginal areas.