VOLUME 1 SECTION I: Veterinary Medicine Worldwide 1. Client Communication 2. The Medical History 3. The Physical Examination 4. Evidence-Based Medicine 5. Biomedical Statistics and Veterinary Literature 6. Pain Medicine: Key Concepts 7. Antimicrobial Stewardship 8. International Travel 9. Health Concerns of Imported Pets SECTION II: Differential Diagnosis General 10. “Ain't Doin' Right”: The Nonspecific Chief Concern of Ill Thrift 11. Distinguishing Behavioral Disorders From Medical Disorders 12. Dermatologic Manifestations of Systemic Disease 13. Ophthalmic Manifestations of Systemic Disease 14. Neurologic Manifestations of Systemic Disease 15. Intoxication Versus Acute Nontoxicologic Illness: Differentiating the Two 16. Fever 17. Anorexia 18. Weight Loss 19. Polyphagia 20. Weight Gain 21. Abdominal Enlargement 22. Failure to Grow 23. Weakness 24. Restlessness 25. Pallor 26. Hyperemia 27. Cyanosis 28. Jaundice 29. Petechiae and Ecchymoses 30. Peripheral Edema 31. Orthopedic Manifestations of Systemic Disease 32. Swollen Joints and Joint Pain 33. Body Odors Cardiorespiratory 34. Cough 35. Sneezing and Nasal Discharge 36. Epistaxis and Hemoptysis 37. Tachypnea, Dyspnea and Respiratory Distress 38. Abnormal Heart Sounds and Heart Murmurs 39. Pulse Alterations 40. Syncope Neurologic 41. Movement Disorders 42. Tremors 43. Ataxia, Paresis, and Paralysis 44. Stupor and Coma 45. Seizures Gastrointestinal 46. Halitosis and Ptyalism 47. Gagging and Dysphagia 48. Regurgitation and Vomiting 49. Diarrhea 50. Melena and Hematochezia 51. Constipation, Tenesmus, Dyschezia, and Fecal Incontinence 52. Flatulence Urogenital 53. Polyuria and Polydipsia 54. Pollakiuria, Stranguria, and Urinary Incontinence 55. Hematuria and Other Conditions Causing Discolored Urine 56. Vulvar and Preputial Discharge SECTION III: Differential Diagnosis for Clinicopathologic Abnormalities 57. Anemia and Erythrocytosis 58. Leukopenia, Leukocytosis 59. Thrombocytopenia, Thrombocytosis 60. Hypoproteinemia and Hyperproteinemia 61. Hypoglycemia and Hyperglycemia 62. Blood Urea Nitrogen, Creatinine, and SDMA 63. Cholesterol and Triglycerides 64. Amylase and Lipase 65. Liver Enzymes 66. Creatine Kinase 67. Sodium and Chloride 68. Potassium, Magnesium 69. Calcium and Phosphorus 70. Urinalysis 71. Fluid Analysis: Thoracic, Abdominal, Joint SECTION IV: Techniques General 72. Body and Muscle Condition Scoring 73. Point-of-Care Ultrasound Examination 74. Venous and Arterial Puncture 75. Jugular Catheterization and Central Venous Pressure Measurement 76. Intraosseous Catheters 77. Constant Rate Infusions 78. Glucose Monitoring 79. Buccal Mucosal Bleeding Time 80. Fecal Examination 81. Nasoesophageal, Esophagostomy, Gastrostomy, and Jejunostomy Tubes: Placement Techniques Skin 82. Otoscopy, Ear Flushing, and Myringotomy 83. Scrapings, Fine-Needle Aspirations, and Biopsies of Skin and Subcutaneous Tissues General Centesis and Biopsy 84. Bone Marrow Aspiration and Biopsy 85. Cytology of Internal Organs 86. Abdominocentesis 87. Arthrocentesis 88. Lymph Node Aspiration and Biopsy 89. Rhinoscopy, Nasal Flush, and Biopsy Respiratory/Cardiovascular 90. Respiratory and Inhalant Therapy 91. Blood Pressure Measurement 92. Thoracocentesis and Thoracostomy Tube Placement 93. Transtracheal Wash and Bronchoscopy 94. Temporary Tracheostomy Care 95. Pericardiocentesis 96. Electrocardiography 97. Echocardiography Renal/Urogenital 98. Urine Collection and Urinary Catheter Management 99. Unblocking the Urethra 100. Cystoscopy and Urethroscopy 101. Vaginoscopy and Vaginal Cytology 102. Peritoneal Dialysis 103. Hemodialysis/Continuous Renal Replacement Therapy 104. Prostatic Diagnostic Techniques Gastrointestinal 105. Gastric Intubation and Lavage 106. Canine Fecal Microbiota Transplantation 107. Gastrointestinal Endoscopy 108. Enemas and Deobstipation Neurologic 109. Cerebrospinal Fluid Collection, Analysis, and Myelography 110. Muscle and Nerve Biopsy 111. Electromyography and Nerve Conduction Velocity 112. Neuroimaging: Radiography, Myelography, Computed Tomography, and Magnetic Resonance Imaging SECTION V: Minimally Invasive Interventional Therapies 113. Overview of Interventional Medicine (Interventional Radiology/Interventional Endoscopy) 114. Respiratory Interventional Therapies 115. Cardiovascular Interventional Therapies 116. Gastrointestinal and Hepatobiliary Interventional Therapies 117. Urologic Interventional Therapies 118. Neoplastic Interventional Therapies SECTION VI: Emergency Medicine 119. Triage and Initial Stabilization 120. Fluid Therapy 121. Circulatory Shock: Identification and Management 122. Diagnostic Testing for the Emergency Patient 123. Respiratory Crisis 124. Bleeding Crisis 125. Neurologic Crisis 126. Abdominal Crisis 127. Lower Urinary Tract Crisis 128. Sepsis and the Systemic Inflammatory Response Syndrome 129. Anaphylaxis 130. Hyperthermia and Hypothermia 131. Cardiopulmonary Arrest and Cardiopulmonary Resuscitation (CPR) SECTION VII: Toxicology 132. Toxin Exposure Therapy/Decontamination 133. Neurotoxicoses 134. Hepatotoxicoses 135. Renal Toxicoses 136. Gastrointestinal Toxicoses 137. Cardiorespiratory Toxicoses 138. Hematologic Toxicoses SECTION VIII: Clinical Pharmacology and Therapeutics 139. Principles of Drug Disposition and Pharmacokinetics 140. Antibacterial Drug Therapy 141. Antifungal and Antiviral Therapy 142. Antiparasitic Drugs 143. Anti-Inflammatory Drugs 144. Immunosuppressive Drugs SECTION IX: Nutrition and Dietary Therapy 145. Nutritional Assessment 146. Neonatal and Pediatric Nutrition 147. Nutrition for Healthy Adult Dogs 148. Nutrition for Healthy Adult Cats 149. Nutrition in Healthy Senior Cats and Dogs 150. Obesity 151. Cachexia and Sarcopenia 152. Nutritional Management of Gastrointestinal Disease 153. Nutritional Management of Exocrine Pancreatic Disease 154. Nutritional Management of Hepatobiliary Diseases 155. Nutritional Management of Endocrine and Metabolic Diseases 156. Nutritional and Medical Considerations in Hyperlipidemia 157. Nutritional Management of Heart Disease 158. Nutritional Management of Renal Disease 159. Nutritional Management of Lower Urinary Tract Disease 160. Nutritional Management of Dermatologic Disease 161. Nutrition for Neurologic Disease and Cognitive Disorders 162. Nutrition-Related Skeletal Disorders 163. Nutritional Management of Cancer 164. Critical Care Nutrition 165. Nutritional Uses of Fiber 166. Adverse Reactions to Foods: Allergies Versus Intolerance 167. Less Conventional Diets 168. Immunology and Nutrition SECTION X: Hematologic and Immunologic Disease 169. Immunologic and Hematologic Disease: Intro and Drug Therapy 170. Coagulation Testing 171. Hyper- and Hypocoagulable States 172. Nonregenerative Anemia 173. Erythrocytosis and Primary Polycythemia 174. Immune-Mediated Hemolytic Anemia and Other Regenerative Anemias 175. Immune Thrombocytopenia, von Willebrand Disease, and Other Platelet Disorders 176. Nonneoplastic White Blood Cell Disorders and Pancytopenia 177. Immune-Mediated Polyarthritis and Other Polyarthropathies 178. Immune-Mediated Dermatologic Diseases 179. Systemic Lupus Erythematosus 180. Immunodeficiencies 181. Vasculitides 182. Diseases of the Spleen SECTION XI: Infectious Disease General 183. Does This Dog or Cat Have an Infectious Disease? 184. Laboratory Diagnosis of Infectious Disease 185. Companion Animal Vaccinations 186. Hospital-Associated (Nosocomial) Infections Bacterial Diseases 187. Lyme Disease 188. Mycobacterial Infections, Actinomycosis, and Nocardiosis 189. Brucellosis 190. Tetanus and Botulism 191. Bartonellosis 192. Leptospirosis 193. Ehrlichiosis, Anaplasmosis, Rocky Mountain Spotted Fever, and Neorickettsiosis 194. Hemotropic Mycoplasmas 195. Enteric Bacterial Diseases Protozoal Diseases 196. Enteric Protozoan Diseases 197. Systemic Protozoal Diseases Viral Diseases 198. Feline Immunodeficiency Virus Infection 199. Feline Leukemia Virus Infection 200. Coronavirus Infection 201. Canine and Feline Parvovirus Infection 202. Rabies 203. Canine Infectious Respiratory Disease Complex 204. Canine Distemper 205. Feline Upper Respiratory Infections 206. Emerging Viral Infections of Cats Fungal Diseases 207. Cryptococcosis 208. Coccidioidomycosis 209. Blastomycosis and Histoplasmosis 210. Sinonasal and Sino-Orbital Aspergillosis 211. Disseminated Invasive Aspergillosis and Systemic Mold Infections VOLUME 2 SECTION XII: Respiratory Disease 212. Clinical Evaluation of the Respiratory Tract 213. Diseases of the Nose, Sinuses, and Nasopharynx 214. Laryngeal Diseases 215. Large Airways Diseases 216. Small Airway Diseases 217. Pulmonary Parenchymal Diseases 218. Pulmonary Hypertension 219. Pulmonary Thromboembolism 220. Pleural Space Diseases 221. Aerodigestive Disorders 222. Diseases of the Mediastinum, Chest Wall, and Diaphragm SECTION XIII: Comorbidities 223. Heart Disease and Kidney Disease 224. Comorbidities: Diabetes Mellitus and Corticosteroid-Responsive Disease 225. Feline Triaditis 226. Obesity and Immobility 227. Concurrent Infection and Immune Suppression SECTION XIV: Cardiovascular Disease 228. Pathophysiology of Heart Failure 229. Heart Failure: Diagnosis and Management 230. Cardiac Arrhythmias 231. Congenital Heart Disease 232. Valvular Heart Diseases of Adult Dogs and Cats 233. Myocardial Diseases of Dogs 234. Feline Myocardial Diseases 235. Pericardial Diseases 236. Systemic Hypertension 237. Heartworm Disease in Dogs and Cats 238. Arterial Thromboembolic Disease 239. Venous and Lymphatic Disorders SECTION XV: Neurologic Disease 240. Neurophysiology 241. Neurologic Examination and Neuroanatomic Diagnosis 242. Inflammatory, Infectious, and Other Multifocal Brain Diseases 243. Vascular Brain Diseases 244. Developmental, Degenerative and Metabolic Brain Diseases and Sleep Disorders 245. Neoplastic Brain Diseases 246. Traumatic Brain Disease 247. Epilepsy 248. Vestibular Disease 249. Cranial Neuropathies 250. Spinal Cord Diseases: Congenital (Developmental), Inflammatory, and Degenerative Disorders 251. Spinal Cord Diseases: Traumatic, Vascular, and Neoplastic 252. Peripheral Neuropathies 253. Neuromuscular Junction Disorders 254. Autonomic Nervous System Disorders 255. Unique Feline Neurologic Disorders 256. Physical Therapy and Rehabilitation SECTION XVI: Gastrointestinal Disease 257. Laboratory Evaluation of the Gastrointestinal Tract 259. Pharyngeal and Esophageal Diseases 260. Host-Microbial Interactions in Gastrointestinal Health 261. Gastric Diseases 262. Small Intestinal Diseases 263. Diseases of the Large Intestine 264. Rectoanal Diseases 265. Peritoneal Diseases SECTION XVII: Hepatobiliary Disease 266. Pathophysiology of Liver Disease 267. Congenital Vascular Liver Diseases 268. Congenital Ductal Plate Abnormalities 269. Acute Toxic and Other Parenchymal Liver Disease 270. Chronic Hepatitis in Dogs 271. Chronic Hepatic Diseases in Cats 272. Infectious Biliary Tract and Gallbladder Disease 273. Non-Infectious Biliary Tract and Gallbladder Disease 274. Vacuolar Hepatopathies 275. Neoplasia of the Liver and Biliary Tree SECTION XVIII: Pancreatic Disease 276. Pancreatitis: Etiology, Pathogenesis, and Pathophysiologic Consequences 277. Pancreatitis in Dogs: Diagnosis and Management 278. Pancreatitis in Cats 279. Exocrine Pancreatic Insufficiency and Rare Conditions of the Exocrine Pancreas SECTION XIX: Endocrine Disease 280. Growth Hormone Disorders in Cats 281. Canine Growth Hormone Disorders 282. Diabetes Insipidus 283. Primary Hyperparathyroidism 284. Hypoparathyroidism 285. Hypothyroidism in Dogs 286. Feline Hypothyroidism 287. Hyperthyroidism in Cats 288. Canine Hyperthyroidism 289. Insulin-Secreting Tumors 290. Diabetic Ketoacidosis and the Hyperosmolar Hyperglycemic State 291. Diabetes Mellitus in Dogs 292. Diabetes Mellitus in Cats 293. Hyperadrenocorticism (Cushing's Syndrome) in Dogs 294. Feline Hyperadrenocorticism 295. Non-Cortisol Secreting Adrenocortical Tumors 296. Hypoadrenocorticism 297. Gastrointestinal Endocrinology 298. Pheochromocytoma SECTION XX: Renal Disease 299. Clinical Approach and Laboratory Evaluation of Renal Disease 300. Acute Kidney Injury 301. Chronic Kidney Disease 302. Glomerular Diseases 303. Renal Tubular Diseases 304. Pyelonephritis 305. Familial and Congenital Renal Diseases of Cats and Dogs SECTION XXI: Lower Urinary Tract Disease 306. Ureteral Disorders 307. Lower Urinary Tract Infections 308. Lower Urinary Tract Urolithiasis in Dogs 309. Lower Urinary Tract Urolithiasis-Feline 310. Diseases of Abnormal Micturition 311. Feline Idiopathic/Interstitial Cystitis 312. Urethral Disorders 313. Congenital Lower Urinary Tract Disorders 314. Prostatic Diseases 315. Reproductive Disorders in Neutered Male and Female Dogs and Cats SECTION XXII: Cancer 316. Tumor Biology 317. Principles and Practice of Chemotherapy 318. Principles and Practice of Radiation Oncology 319. Cancer Immunotherapy 320. Molecular Targeted Therapy 321. Complications of Cancer Therapy 322. Hematopoietic Tumors 323. Tumors of the Skin 324. Soft Tissue Sarcomas 325. Hemangiosarcoma 326. Primary Bone Tumors in Dogs 327. Mast Cell Disease 328. Canine and Feline Histiocytic Diseases 329. Mammary Gland Tumors 330. Urogenital Tumors 331. Paraneoplastic Syndromes