The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019.

High-throughput genomics: bioinformatic tools and medical applications.- A Coarse-Grained Representation for Discretizable Distance Geometry with Interval Data.- Fragment-based Drug Design to Discover Novel Inhibitor of Dipeptidyl Peptidase-4 as a Potential Drug for Type 2 Diabetes Therapy.- Discovery of Novel Alpha-Amylase Inhibitors For Type II Diabetes Mellitus Through The Fragment-Based Drug Design.- Compression of Nanopore FASTQ files.- De novo Transcriptome Global Assembly of Solea senegalensis v5.0 Using TransFlow.- Deciphering the role of PKC in calpain-CAST system through formal modeling approach.- The Application of Machine Learning Algorithms to Diagnose CKD Stages and Identify Critical Metabolites Features.- Expression change correlations between transposons and adjacent genes in lung cancer reveal a genomic location dependence and highlights cancer-significant genes.- Signal processing based CNV detection in bacterial genomes.- Omics data acquisition, processing, andanalysis.- Dependency Model for Visible Aquaphotomics.- Image based individual identification of Sumatra barb (Puntigrus tetrazona).- Alignment of Sequences Allowing for Non-Overlapping Unbalanced Translocations of Adjacent Factors.- Probability in HPLC-MS metabolomics.- Pipeline for Electron Microscopy Images Processing.- A Greedy Algorithm for Detecting Mutually Exclusive Patterns in Cancer Mutation Data.- Qualitative Comparison of Selected Indel Detection Methods for RNA-Seq Data.- Structural and functional features of glutathione reductase transcripts from olive (Olea europaea L.) seeds.- Bioinformatics approaches for analyzing cancer sequencing data.- Prediction of thermophilic proteins using voting algorithm.- Classifying Breast Cancer Histopathological Images Using A Robust Artificial Neural Network Architecture.- Spatial Attention Lesion Detection on Automated Breast Ultrasound.- Essential Protein Detection from Protein-Protein Interaction Networks Using Immune Algorithm.- Integrating multiple datasets to discover stage-specific cancer related genes and stage-specific pathways.- Integrated detection of copy number variation based on assembly of NGS and 3GS data.- Protein Remote Homology Detection based on Profiles.- Next generation sequencing and sequence analysis.- Reads in NGS are distributed over a sequence very inhomogeneously.- Differential Expression Analysis of ZIKV Infected Human RNA Sequence Reveals Potential Genetic Biomarkers.- Identification of Immunoglobulin Gene Usage in Immune Repertoires Sequenced by Nanopore Technology.- Flexible and Efficient Algorithms for Abelian Matching in Genome Sequences.- Analysis of gene regulatory networks inferred from ChIP-seq data.- Structural Bioinformatics and Function.- Function vs. taxonomy: the case of fungi mitochondria ATP synthase genes.- Non-Coding Regions of Chloroplast Genomes Exhibit a Structuredness of Five Types.- Characteristics of Protein Fold Space Exhibits Close Dependence on Domain Usage.- Triplet Frequencies Implementation in Total Transcriptome Analysis.- A hierarchical and scalable strategy for protein structural classification.- Protein structural signatures revisited: geometric linearity of main chains are more relevant to classification performance than packing of residues.- Telemedicine for Smart Homes and Remote Monitoring.- Positioning Method for Arterial Blood Pressure Monitoring Wearable Sensor.- Study of the detection of falls using the SVM algorithm, different datasets of movements and ANOVA.- Influence of illuminance on sleep onset latency in IoT based lighting system environment.- Clustering and analysis of Biological Sequences with Optimization Algorithms.- Efficient online Laplacian eigenmap computation for dimensionality reduction in molecular phylogeny via optimisation on the sphere.- PROcket, an efficient algorithm to predict Protein Ligand Binding Site.- Gene Expression High-Dimensional Clustering towards a Novel, Robust, Clinically Relevant and HighlyCompact Cancer Signature.- Computational Approaches for Drug Repurposing and Personalized Medicine.- When Mathematics Outsmarts Cancer.- Influence of the stochasticity in the model on the certain drugs pharmacodynamics.- Graph Model for the Identification of Multi-Target Drug Information for Culinary Herbs.- On Identifying Candidates for Drug Repurposing for the Treatment of Ulcerative Colitis using Gene Expression.