This book constitutes the proceedings of the 18th International Conference on Research Challenges in Information Sciences, RCIS 2024, which took place in Guimarães, Portugal, during May 2024. The scope of RCIS is summarized by the thematic areas of information systems and their engineering; user-oriented approaches; data and information management; business process management; domain-specific information systems engineering; data science; information infrastructures, and reflective research and practice. The 25 full papers, 12 Forum and 5 Doctoral Consortium papers included in these proceedings were carefully reviewed and selected from 100 submissions. They were organized in topical sections as follows: Part I: Data and information management; conceptual modelling and ontologies; requirements and architecture; business process management; data and process science; security; sustainability; evaluation and experience studies Part II: Forum papers; doctoral consortium papers.