This book constitutes the refereed proceedings of the Second International Conference on Innovative Technologies and Learning, ICITL 2020, held in Porto, Portugal, in November 2020. The 65 full papers presented together with 2 short papers were carefully reviewed and selected from 127 submissions. The papers are organized in the following topical sections: Augmented and Virtual Reality in Education; Educational Data Mining and Learning Analytics; Emerging Issues and Trends in Education; Innovative Learning in Education; Online Course and Web-Based Environment; Technology-Enhanced Learning; Application and Design of Innovative Learning Software; and Science, Technology, Engineering, Arts and Design, and Mathematics.Due to the Corona pandemic this event was held virtually.