This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer’s disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer’s disease.Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer’s agents Explains the role of phytomolecules and natural products in Alzheimer’s therapy Reviews preclinical ways to assess drugs focusing on Alzheimer’s disease Covers biomarker analysis for Alzheimer’s disease Discusses the onset and progression of Alzheimer’s diseaseThe book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.
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This reference book compiles the recent advances in computational and experimental modeling to screen and manage Alzheimer's disease. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency.
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Chapter 1: Alzheimer's Disease: Epidemiology, Neuropathology, and NeurochemistryRaushan Kumar Chaudhary, Uday Venkat Mateti, Pukar Khanal, Kala Bahadur Rawal, Praneetha Jain, Vishal S Patil, Amit Kumar Shrivastava and B M PatilChapter 2: Preclinical Approach: In vivo and In vitro Methods for Evaluation of Anti-Alzheimer's DrugsNilutpal Sharma Bora, Bhargab Jyoti Sahariah, Chanam Melody Devi and Banshongdor H. MawliehChapter 3: Computational Insights into the Applications of Plant-Based Therapies in Alzheimer's DiseaseDibyajyoti Das, Satyendra Deka, Biswajit Devanath, Aparoop Das, Nongmaithem Randhoni Chanu and Ramen KalitaChapter 4: Advances in Applying Computer-Aided Drug Design for Alzheimer’s DiseaseBiswajit Devanath, Satyendra Deka, Dibyajyoti Das, Hans Raj Bhat, Nongmaithem Randhoni Chanu and Kunal BhattacharyaChapter 5: Biomarkers Analysis for Alzheimer's DiseaseShraddha M. Jadhav and Karan KumarChapter 6: Mechanistic Aspects of Neurodegeneration in Alzheimer's Disease and the Role of PhytochemicalsTrideep Saikia, Tutumoni Kalita, Bhanu P Sahu, Prakash Rajak, Bhargab Deka and Alakesh BharaliChapter 7: Computational Modelling of BACE-1, AChE, and Phosphodiesterase Inhibitors as Anti-Alzheimer's AgentsVishal S Patil, Jagadeesh Dodakallanavar, Pukar Khanal, B M Patil, Raushan K Chaudhary, Amit Kumar Shrivastava, Nongmaithem Randhoni Chanu, Darasaguppe R. Harish and Uday Venkat MatetiChapter 8: Therapeutic Application of Natural Products in Alzheimer’s Disease Using Computational MethodsMuhammad Aqib Shabbir, Muhammad Naveed, Maleeha Manzoor, Hafiz Muhammad Hurraira, Noor-ul-Ain and Fatima ZaidiChapter 9: Analysis of Potential Alzheimer's Disease Inhibitors Based on Computational Modelling with Multiple TargetsAnkita Dubey, Vrishti M Thakur, Raja Chakraborty, G.N. Darwhekar, Rupesh Kushwah and Rakhi KhabiyaChapter 10: Virtual Screening: Pioneering the Future of Drug Discovery in Alzheimer's DiseaseN. Yellasubbaiah, B. Sivakumar and B. NagasudhaIndex
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Produktdetaljer

ISBN
9781032530079
Publisert
2024-03-29
Utgiver
Vendor
CRC Press
Vekt
453 gr
Høyde
254 mm
Bredde
178 mm
Aldersnivå
U, P, 05, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
190

Biographical note

Kunal Bhattacharya is currently working as assistant professor in Pratiksha Institute of Pharmaceutical Sciences, Assam, India. His area of specialization includes Computer aided drug design, Bioinformatics and Analytical Chemistry. He obtained his M.Pharm in Pharmaceutical Chemistry from Nitte University, Mangalore, India. He is currently pursuing his PhD in pharmaceutical sciences in neurodegenerative diseases from The Assam Royal Global University, Assam, India.

Atanu Bhattacharjee is currently working as a professor at School of Pharmacy, The Assam Royal Global University, Assam, India. He is considered as pioneer in the field of pharmacognosy and phytochemistry. Dr. Bhattacharjee achieved his Ph.D in Pharmaceutical Sciences in the areas of phytochemistry and neuro-pharmacology from Nitte University, Mangalore, India. He worked extensively on various in silico, in vitro and in vivo experiments to encounter neuro-degenerative disorders like Alzheimer’s disease with folklore medicine from the Indian diaspora and to determine safety profiles and standardize medicinal plants.