This book constitutes the post-conference proceedings of the 4th International Conference on Advances in Computing and Data Sciences, ICACDS 2020, held in Valletta, Malta, in April 2020.*The 46 full papers were carefully reviewed and selected from 354 submissions. The papers are centered around topics like advanced computing, data sciences, distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations.* The conference was held virtually due to the COVID-19 pandemic.