Tourette Syndrome covers all of the main aspects related to TS, analyzing the complexity of its clinical presentation, the novel viewpoints of causes and mechanisms, the best way to assess TS patients, and the multifaceted and multidisciplinary treatment options.

TABLE OF CONTENTS ; Foreword ; Introduction ; SECTION 1 CLINICAL PHENOMENOLOGY AND EPIDEMIOLOGY ; Chapter 1 Phenomenology of tics and sensory urges: the self under siege ; James F Leckman, Michael H Bloch, Denis G Sukhodolsky, Lawrence Scahill, Robert A King (Child Study Center, Yale University, New Haven, CT, USA) ; Chapter 2 The phenomenology of attention deficit hyperactivity disorder in Tourette syndrome ; Aribert Rothenberger (University of Gottingen, Germany) and Veit Roessner (University Medical Center, Dresden, Germany) ; Chapter 3 The phenomenology of obsessive-compulsive symptoms in Tourette syndrome ; Ygor A Ferrao (Universidade Federal de Ciencias de Saude de Porto Alegre, Brazil), Pedro G de Alvarenga, Ana G Hounie, Maria Alice de Mathis, Maria C de Rosario and Euripedes Miguel (University of Sao Paulo Medical School, Brazil) ; Chapter 4 Other psychiatric co-morbidities in Tourette syndrome ; Danielle Cath (Utrecht University, The Netherlands) and Andrea Ludolph (University of Ulm, Germany) ; Chapter 5 Clinical course and adulthood-outcome in Tourette syndrome ; Michael Bloch (Yale Child Study Center, New Haven, CT, USA) ; Chapter 6 Prevalence and methods for population screening ; Lawrence Scahill (Yale Child Study Center, New Haven, CT, USA) and Soren Dalsgaard (Denmark) ; SECTION 2 ETIOLOGY ; Chapter 7 Genetic susceptibility in Tourette syndrome ; Thomas Fernandez and Matthew W State (Child Study Center, Yale University, New Haven, CT, USA) ; Chapter 8 Perinatal adversities and Tourette syndrome ; Pieter J Hoekstra (University of Groningen, The Netherlands) ; Chapter 9 Infections and tic disorders ; Tanya K Murphy (University of Florida College of Medicine, Gainesville, FA, USA) ; SECTION 3 PATHOPHYSIOLOGY ; Chapter 10 Cellular and molecular pathology in Tourette syndrome ; Flora M Vaccarino, Yuko Kataoka and Jessica Lennington (Child Study Center, Yale University, New Haven, CT, USA) ; Chapter 11 Electrophysiology in Tourette syndrome ; Michael Orth (University of Ulm, Germany) ; Chapter 12 Neurobiology and functional anatomy of tic disorders ; Deanna J Greene, Kevin J Black, Bradley L Schlaggar (University of Washington, St. Louis, MO, USA) ; Chapter 13 The Neurochemistry of Tourette syndrome ; Harvey S Singer (Johns Hopkins University School of Medicine, Baltimore, MD, USA) ; Chapter 14 Immunity and stress response in Tourette syndrome ; Davide Martino (Queen Mary University of London, London, UK) ; Chapter 15 Animal models of tics ; Kevin W McCairn, Yukio Imamura and Masaki Isoda (Okinawa Institute of Science and Technology, Okinawa, Japan) ; SECTION 4 DIAGNOSIS AND ASSESSMENT ; Chapter 16 Whither the relationship between etiology and phenotype in Tourette syndrome? ; Mary M Robertson (St. George's Hospital and Medical School, London, UK) and Valsamma Eapen (University of New South Wales, Sydney, Australia) ; Chapter 17 The differential diagnosis of tic disorders ; Roger Kurlan (Atlantic Neuroscience Institute, Summit, NJ, USA) ; Chapter 18 Comprehensive assessment strategies ; Robert A King and Angeli Landeros-Weisenberger (Child Study Center, Yale University, New Haven, CT, USA) ; Chapter 19 Clinical rating instruments in Tourette syndrome ; Andrea E Cavanna and John CP Piedad (University of Birmingham, Birmingham, UK) ; Chapter 20 Neuropsychological assessment in Tourette syndrome ; Tara Murphy (Great Ormond Street Hospital for Children, London, UK) and Clare Eddy (University of Birmingham, Birmingham, UK) ; Chapter 21 Social and adaptive functioning in Tourette syndrome ; Denis G Sukhodolsky, Virginia W Eicher and James F Leckman (Child Study Center, Yale University, New Haven, CT, USA) ; SECTION 5 TREATMENT ; Chapter 22 Psychoeducational interventions: what every parent and family member needs to know ; Eli R Lebowitz and Lawrence Scahill (Child Study Center, Yale University, New Haven, CT, USA) ; Chapter 23 Cognitive-behavioural treatment for tics ; Matthew R Capriotti and Douglas W Woods (University of Wisconsin, Milwaukee, WI, USA) ; Chapter 24 Pharmacological treatment of tics ; Veit Roessner (University Medical Center, Dresden, Germany) and Aribert Rothenberger (University of Gottingen, Germany) ; Chapter 25 Treatment of psychiatric co-morbidities in Tourette syndrome ; Francesco Cardona (University of Rome <"La Sapienza>", Rome, Italy) and Renata Rizzo (University of Catania, Catania, Italy) ; Chapter 26 Surgical treatment of Tourette syndrome ; Mauro Porta, Marco Sassi and Domenico Servello (IRCCS Galeazzi, Milan, Italy) ; Chapter 27 Alternative treatments in Tourette syndrome ; Beata Zolovska and Barbara Coffey (NYU Child Study Center, New York City, NY, USA) ; SECTION 6 RESOURCES & SUPPORT ; Chapter 28 Information and social support for patients and families ; Kirsten Muller-Vahl (Hannover Medical School, Hannover, Germany) ; Chapter 29 Information and support for educators ; Sheryl K Pruitt (Parkaire Consultants, Marietta, GA, USA) and Leslie E Packer (Tourette Syndrome Association, Long Island Chapter) ; Chapter 30 Tourette syndrome support organisations around the world ; Louise Roper (University of Birmingham, Birmingham, UK), Peter Hollenbeck (Purdue University, West Lafayette, IN, USA) and Hugh Rickards (University of Birmingham, Birmingham, UK)

Tourette Syndrome (TS)... is evident at every level, from behavior to molecules, and it has soundly rebuffed every effort to view it otherwise... Perhaps no single investigator is more responsible for bringing a deeper awareness of TS to our field than is Dr. James Leckman. In this comprehensive text, Martino and Leckman embrace the complexities of TS, engaging a world-class group of clinicians and scientists to update us on its various clinical presentations, likely etiologies, diagnostic strategies and multimodal treatments, closing with a section describing important community-based resources for TS patients, families, educators, scientists and clinicians. This is an invaluable source text on Tourette Syndrome, and a primer on how to understand complex neuropsychiatric phenotypes, for readers in Psychiatry, Neurology and Pediatrics, from trainees to senior practitioners. -- Neal R. Swerdlow, MD, PhD, Professor of Psychiatry, University of California, San Diego "Davide Martino and James Leckman have done a superb job in bringing together authoritative authors and have set the contemporary agenda for treatment and study of Tourette syndrome. Comprehensive and critical reviews of the evidence are presented with fresh thinking spanning the whole range from molecular biology to classroom management. Clinicians and investigators will want to turn to this book, to the benefit of our patients." -- Dr. Jeremy S. Stern, Neurologist and Honorary Medical Director, Tourettes Action, Surrey, UK This seminal volume covers all relevant aspects (and more) concerning TS and will set standards for many years to come. Several chapters include case vignettes which makes for an easy and practical read. Especially interesting are the "Questions for future research" which conclude each chapter and will surely pave the way for much of the relevant science that needs to be conducted on TS over the next ten to twenty years. Also, the fact that the TS research and clinical community now spans the globe is well reflected by this book and should inspire hope in all TS sufferers and their families. Overall, I am confident that this volume will become an invaluable resource for myself and my colleagues, both in specialist and non-specialist settings. Highly recommended and much applauded. -- Andreas Hartmann, MD, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, France Tourette Syndrome is a comprehensive multi-author book relevant to the understanding and management of people with Tourette syndrome. The book covers all aspects of Tourette syndrome including clinical phenomenology, co-morbidity, pathophysiology, therapy and support... provides in depth analysis and updates on genetics, neurochemistry and neuroimmunology, but also provides equal priority to the practicalities of management including family support and psychoeducation. The 'balance' of the book is excellent, and demonstrated by the therapeutic sections that discuss the merits and challenges of pharmacological and surgical approaches, but also the exciting and emerging psychological and behavioural therapies. The excellent editorial tone is apparent... This book is a 'Tour de force' in Tourette syndrome, and a must-have for people who care about this disorder. -- Russell C. Dale, Paediatric Movement Disorder Service, Children's Hospital at Westmead, University of Sydney, Australia "This is probably the most comprehensive, important, and valuable book ever written on Tourette syndrome. The editors and ... contributors ... have done a marvelous job indeed." --Biz India

Selling point: The content of the chapters is conceived as a comprehensive and objective review of the literature: the reader has access to an unbiased summary of the current knowledge on Tourette syndrome Selling point: A valuable learning source for students and a useful inspiration for researchers working in the field. Selling point: Includes chapters written by an outstanding selection of clinicians and researchers from all over the world

Dr. Davide Martino is a Clinical Lecturer at Queen Mary University of London and Consultant Neurologist at the South London NHS Trust. His clinical and research activity is devoted to Tourette syndrome and other movement disorders. He is a co-founder of the European Society for the Study of Tourette syndrome (ESSTS) and has published more than 70 articles, many of which focused on phenomenology, immunological aspects and imaging of Tourette syndrome. James F. Leckman is Neison Harris Professor in the Child Study Center and Professor of Pediatrics and of Psychiatry at Yale University School of Medicine, New Haven, CT.

Selling point: The content of the chapters is conceived as a comprehensive and objective review of the literature: the reader has access to an unbiased summary of the current knowledge on Tourette syndrome Selling point: A valuable learning source for students and a useful inspiration for researchers working in the field. Selling point: Includes chapters written by an outstanding selection of clinicians and researchers from all over the world