Now published in its Second Edition, the Textbook of Clinical Trials offers detailed coverage of trial methodology in diverse areas of medicine in a single comprehensive volume. Praise for the First Edition: ".

List of Contributors ix Preface to Second Edition xvii Preface the First Edition xix Introduction 1 1 The Development of Clinical Trials 3 Simon Day 2 General Statistical Issues 13 David Machin 3 The Cochrane Collaboration 39 Mike Clarke Cancer 47 4 Breast Cancer 49 Donald A. Berry, Terry L. Smith and Aman U. Buzdar 5 Childhood Cancer 63 Sharon B Murphy and Jonathan J.Shuster 6 Gastrointestinal Cancers 81 Daniel Sargent, Richard Goldberg and Paul Limburg 7 Melanoma 105 Ping-Yu Liu and Vernon K. Sondak 8 Respiratory Cancers 121 Joan H. Schiller and Kyungmann Kim 9 Adrenal Cortical Carcinoma 137 Isha Malik and Petros Perros 10 Thyroid Cancer 143 Vijayaraman Arutchelvam and Petros Perros 11 Urologic Cancers 149 Edith D. Canby-Hagino, Catherine M. Tangen, and Ian M. Thompson 12 Haematologic Cancers: Challenges in Developing New Therapeutic Approaches 167 Charles A. Schiffer and Stephen L. George Cardiology 177 13 Acute Stroke 179 Philip Bath 14 Cardiovascular Disease 215 Krishna Prasad Dentistry and Oral Health Care 241 15 Dentistry and Oral Health Care 243 May C.M. Wong, Colman McGrath and Edward C.M. Lo Dermatology 261 16 Dermatology 263 Luigi Naldi and Cosetta Minelli Infectious Diseases 287 17 HIV Infection 289 Michael D. Hughes 18 Infectious Diseases 303 Ingela Krantz Ophthalmology 317 19 Ophthalmology 319 Jonathan C.K. Clarke and Peng-Tee Khaw Psychiatry 333 20 Anxiety Disorders 335 M. Katherine Shear and Philip W. Lavori 21 Cognitive Behaviour Therapy 353 Nicholas Tarrier and Til Wykes 22 Psychotherapy for Depression 377 Graham Dunn Reproductive Health 395 23 Contraception 397 Gilda Piaggio and Timothy M.M. Farley 24 Gynaecology and Infertility 421 Siladitya Bhattacharya and Jill Mollison 25 Early Pregnancy Termination 443 Beverly Winikoff and Batya Elul 26 Maternal and Perinatal Health 459 José Villar, Allan Donner, Edgardo Abalos and Liana Campódonico Respiratory 475 27 Respiratory Medicine 477 Anders Källén Surgery & Anaesthesia 517 28 Anaesthesia and Pain 519 Paul S. Myles and John Rigg 29 General Surgery 543 Dr Olga Jonasson and Domenic Reda 30 Plastic Surgery – Reconstructive Surgery 553 Erik Ang and Woffles Wu 31 Plastic Surgery – Aesthetic Surgery 575 Woffles Wu and Erik Ang Transplantation 591 32 Renal Transplantation 593 Vathsala Anantharaman Other Procedures 605 33 Wound Healing 607 Colin Song and Edwin Chan 34 Palliative Care 627 Robert S. Krouse and David Casarett 35 Complementary Medicine 647 Ping-Chung Leung 36 Cluster Randomized Trials in Health Care Research 669 Randall D. Cebul, Neal V. Dawson and Thomas E. Love 37 Nursing 681 Nicola Crichton Special Populations 699 38 Clinical Trials in Paediatrics 701 Johan P.E. Karlberg 39 Clinical Trials Involving Older People 711 Carol Jagger and Antony J. Arthur 40 Clinical Trials in Rare Diseases 723 Simon Day Index 735

Textbook of Clinical Trials second edition continues the original aim, to highlight the varied ways that clinical trials - particularly randomized controlled trials - have influenced the practice of medicine within different therapeutic areas.  It describes the different challenges posed by those conducting clinical trials across a range of medical specialities and allied fields and at the same incorporates the development of clinical trial statistical methodology. The background to each medical speciality is provided, followed by the characteristic problems experienced by trialists in that area.  Case studies are used throughout to provide a comprehensive key text in this rapidly expanding area. This unique way of presenting clinical trial information will make this second edition an essential reference for clinical trialists, whether with administrative, data management and quality, scientific, medical or statistical roles.  In addition it will provide a reference for pharmaceutical industry personnel, members of ethics committees and those who work in regulatory departments. Building on the success of the first edition many new therapeutic areas are included including: General surgery, plastic surgery, aesthetic surgery palliative care, primary care, anaesthesia and pain, transfusion, wound healing, maternal and perinatal health, early termination, organ transplants, ophthalmology, epilepsy, infectious disease, neuro-oncology, adrenal cancer thyroid cancer urological cancer