Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome. The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries.
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1. Historic accounts of neuron regeneration 2. Reagents for neuron regeneration structural studies 3. Assessments for functional regeneration 4. In vitro methods 5. In vivo models and pharmacological reagents 6. Systems biology approaches 7. Application of machine learning and artificial intelligence 8. Standardization approaches 9. Re-connectivity and new approaches 10. Regeneration applicable to other fields 11. Food and drug administration outlook for new treatments in this area 12. Approval processes and clinically relevant aspects 13. Enterprise formation strategies 14. Protocols and miscellaneous topics
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A comprehensive reference to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, and more
Includes updates on the use of multi-omics datasets for selecting molecules for axon regeneration Bridges the preclinical and clinical world, from selection of the molecules to outcome leading to IND filing and their use Includes system level knowledge needed for central nervous system axon and dendrite regeneration, and standardizes the system level biology for axon regeneration Explores the current state of multi-omics in axon and dendrite regeneration in the optic nerve and its comparison to other CNS regeneration
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Produktdetaljer

ISBN
9780443155802
Publisert
2025-01-15
Utgiver
Elsevier Science Publishing Co Inc
Vekt
1290 gr
Høyde
276 mm
Bredde
216 mm
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Heftet
Antall sider
466

Biografisk notat

Sanjoy Bhattacharya is a tenured full Professor at the Department of Ophthalmology, University of Miami, with secondary appointments in biochemistry, molecular biology, neuroscience, cellular and molecular pharmacology programs. He earned his doctorate in Biochemical Engineering and Biotechnology. Dr. Bhattacharya’s laboratory, with its diverse expertise in engineering, computer programming, biology, and mass spectrometry, is dedicated to studying the complete set of molecules and biological systems involved in axon regeneration. He serves on the editorial board of several peer-reviewed journals including PLoS One as an academic editor, Experimental Eye Research as Special issues and Review editor, and Translational Metabolomics as the Editor in Chief. Professor Bhattacharya has held several leadership positions including Chair of the scientific advisory board of Malignancy Research Foundation and Chair of Miller School of Medicine Faculty Council. He is also the founding director of Miami Integrative Metabolomics Research Center.