In this issue of _Clinics in Perinatology_, guest editors Drs. Sagori Mukhopadhyay and Karen M. Puopolo bring their considerable expertise to the topic of PERINATAL AND NEONATAL INFECTIONS. Top experts review the fundamentals of neonatal infections and discuss the changing landscape of infectious disease and its management. Articles cover disease epidemiology, infection-related issues that have come into focus as neonatal practice evolves, the use of genomics to gain understanding of late-onset sepsis pathogenesis, consideration of circadian biology in infection transmission and acquisition, and more. * Contains 13 PRACTICE-ORIENTED TOPICS including infection prevention 101; early onset sepsis and late onset sepsis; probiotic use in the NICU; neonatal-perinatal consequences of COVID-19 and emerging viral infections in the neonatal period; machine learning from EMR: warning systems for neonatal infections; and more. * Provides in-depth CLINICAL REVIEWS OF PERINATAL AND NEONATAL INFECTIONS, offering actionable insights for clinical practice. * Presents the LATEST INFORMATION ON THIS TIMELY, FOCUSED TOPIC under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.