Section I: General Aspects 1. Pathophysiological aspects of calpains in cancer 2. Mitochondrial proteases in cancer development and progression 3. Proteases in Head and Neck Cancer 4. Matrix metalloproteases and uveal melanomas 5. Proteases in DNA damage, repair and radio resistance: Cellular and Molecular aspects 6. Radiotherapy, proteases and gastric cancer: a complex interplay 7. Matrix metalloproteases in the pathogenesis of hepatocarcinoma 8. Exploring synthetic and natural compounds for Cathepsin B: Mechanisms and therapy 9. Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer 10. Ubiquitin –specific protease 3,7 in bone cancer and squamous cell carcinoma 11. Serine protease: structure, classification, mechanism and role in breast cancer Section II: Proteases as Diagnostics and Prognostics Biomarkers 12. Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and novel therapeutic targets for gastric cancer 13. Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer 14. From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis 15. Cathepsins as a diagnostic and prognostic marker in Oral cancer 16. Role of Kallikreins in Prostate Cancer 17. Mechanistic aspects of Serine Protease as biomarkers in wound healing of lung cancer 18. The role of acetylcholinesterase in cancer development and possible therapeutic applications 19. Therapeutics of animal derived compounds in proteases induced cancer 20. Molecular Warriors: Proteases as Sentinels in the War Against Cancer Diagnosis and Prognosis Section III: Proteases, Chemoresistance and Cancer 21. Serine proteases, chemoresistance and cancer 22. Cathepsins, chemoresistance and cancer 23. ix metalloproteases, chemoresistance and cancer 24. MMPs (-2 and -9) mediated drug resistance and their reversal in gynecological cancer 25. The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer 26. Role of the proteasome in the development of chemoresistance in multiple myeloma 27. Role of cysteine cathepsin and matrix metalloproteases in progression and chemoresistance in ovarian and breast cancer 28. Proteases, chemoresistance and cancer 29. Breaking Barriers: Proteases as Key Players in Cancer Chemoresistance Section IV: Other Aspects 30. Matrix metalloproteases-targeting low molecular weight compound 31. Synthetic protease inhibitors in oral, head and neck cancer: evidence from clinical trials. 32. Synthetic protease inhibitors in endocrine and gastroenterology cancers: results of clinical trials 33. Side effects of synthetic protease inhibitors used in gynecology cancers 34. Role of synthetic compounds with protease inhibitory activity in breast cancer 35. Cathepsin responsive nanomaterials for targeted delivery of malignant tumors

Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer development Gives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasis Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry