Part I. Palliative Management: 1. Introduction to palliation; 2. Characteristics of palliation; 3. Nodal points in decision-making for neurological diseases; 4. Potential deficiencies in palliative management in neurology; 5. Common themes in palliation practice; Part II. 1. Fatigue: 2. Problems with muscles and movement; 3. Bulbar symptoms; 4. Respiratory symptoms; 5. Gastro-intestinal symptoms; 6. Urological symptoms; 7. Pain; 8. Cognitive, behavioural and psychological symptoms; 9. Miscellaneous symptoms; Part III. Major Neurological Conditions Requiring Palliation: 1. Cerebrovascular diseases and stroke; 2. Demyelinating diseases (MS); 3. Parkinson's disease and related disorders; 4. Dementia; 5. ALS (motor neurone disease); 6. Viral and prion infections - rabies, HIV, CJD; 7. Muscular dystrophies; 8. Neuropathy; 9. Huntington's disease; 10. Cerebral neoplasms; 11. Sequelae of traumatic brain injury and spinal injury; Part IV. Ethical Issues: 1. Consent and decision-making; 2. Advance directives; 3. Proxy decision-making; 4. Ethical issues in states of altered consciousness; 5. Terminal sedation; 6. Euthanasia; Part V. Appendices: 1. Practical aspects of home care; 2. The criteria for an effective palliation service; 3. Suggested further reading; 4. Medications referred to in the text.