The 20th century has witnessed the great benefits of the development of antibi­ otics, which became a reality after World War IL More than 50 years ago I witnessed the miraculous therapeutic power of penicillin, when I was a student at the Tohoku University Medical School's Department of Bacteriology in Sendai, Japan.

Chemical Structure of the Apoprotein of Neocarzinostatin.- Neocarzinostatin Chromophore: Structure and Mechanism of DNA Cleavage.- Synthesis and Chemistry of Nine-Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics.- Solution Structure of Neocarzinostatin Determined by Homonuclear Two-Dimensional Nuclear Magnetic Resonance.- Three-Dimensional Structure of Neocarzinostatin.- The Biochemical Mechanisms Involved in the Biological Effects Induced by Neocarzinostatin (NCS) and the NCS Chromophore.- Activation of Neocarzinostatin by NADPH Cytochrome P-450 Reductase: Proposal of an Ultimate Mode of Action in Cells Involving Oxygen Free Radicals.- Immunomodulating Antitumor Mechanisms of SMANCS.- Host-Mediated Antitumor Activity Induced by Neocarzinostatin and Its Polymer-Conjugated Derivative in Tumor-Bearing Mice.- Pharmacological Uniqueness and Clinical Effects of Neocarzinostatin.- Metamorphosis of Neocarzinostatin to SMANCS: Chemistry, Biology, Pharmacology, and Clinical Effect of the First Prototype Anticancer Polymer Therapeutic.- Supplementary Materials: Publications on Neocarzinostatin or Related Subjects, in English, 1960–1981.

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