In this issue of _Clinics in Liver Disease_, guest editor Dr. Mitchell L. Shiffman brings his considerable expertise to the topic of NAVIGATING THE MANAGEMENT OF HEPATOCELLULAR CARCINOMA. Incidence rates of hepatocellular carcinoma (HCC) have more than tripled since 1980, and death rates have more than doubled during this time. This issue addresses diagnosis, treatment modalities, and surveillance—all with real-world approaches. Selected articles include case histories, revealing how and why decisions were made. * Contains 12 RELEVANT, PRACTICE-ORIENTED TOPICS including diagnosis and staging of HCC; real-world management of HCC: selected case presentations highlighting the dilemmas of surveillance; systemic therapy for HCC; real-world management of HCC: selected case presentations and how treatment decisions are made; management of chronic liver disease in patients with HCC; and more. * Provides in-depth CLINICAL REVIEWS ON THE MANAGEMENT OF HEPATOCELLULAR CARCINOMA, offering actionable insights for clinical practice. * Presents the LATEST INFORMATION ON THIS TIMELY, FOCUSED TOPIC under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews