Introductory Comments About the authors Preface Meeting the Challenge of Patients with Immune Mediated Liver Disease Keith D. Lindor, keith.lindor@asu.edu Foreword: Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunities Ian R. Mackay, ian.mackay@monash.edu Chapter 1: Core concepts in immunology Cliona O'Farrelly & Derek Doherty Chapter 2: The Geoepidemiology of Autoimmune Liver Disease Carlo Selmi, Cecilia B. Chighizola, Angela Ceribelli, Maria De Santis, Pier Luigi Meroni, & Renqian Zhong Chapter 3: Diagnostic Liver Immunology Christopher Bowlus Chapter 4: The Liver as a Lymphoid Organ Percy Knolle Chapter 5: Innate Immunity and Disorders of the Liver Mathias Heikenwalder, Percy Knolle, & U. Protzer Chapter 6: The Liver and Immune Tolerance Zhigang Tian, Cai Zhang, & Zhe-Xiong Lian Chapter 7: The Diagnosis and Classification of Immune Mediated Hepatic Diseases F. Alvarez Chapter 8: The Diagnosis and Classification of Immune Mediated Biliary Diseases Gideon Hirschfield Chapter 9: Bacterial Infections in Liver Eirini I. Rigopoulou, Daniel S. Smyk, Timoklia Orfanidou, Dimitrios Bogdanos, & M. Eric Gershwin Chapter 10: The Diagnosis and Classification of Parasitic Diseases of the Liver Shyamapada Mandal & Manisha Mandal Chapter 11: Viral Diseases of the Liver Gadi Lalazar & Yaron Ilan Chapter 12: Hepatitis A: Immune response and virus evolution Rosa M. Pinto, Albert Bosch, & Gerardo Kaplan Chapter 13: Immunopathogenesis of Chronic Hepatitis B and the Clinical Events that Shape its Natural History Stevan A. Gonzalez & Robert P. Perrillo Chapter 14: Hepatitis C Mario U. Mondelli, Stefania Varchetta, & Francesco Negro Chapter 15: Immunopathogenesis of Hepatitis D Sebastian Luneman, Jan Grabowski, & Heiner Wedemeyer Chapter 16: Hepatitis E Hiroki Takahashi & Mikio Zeniya Chapter 17: Primary Biliary Cirrhosis Pietro Invernizzi, Patrick S.C. Leung, Ma Xiong, & M. Eric Gershwin, Chapter 18: Autoimmune Hepatitis Diego Vergani, Rodrigo Liberal, & Giorgina Mieli-Vergani Chapter 19: Primary Sclerosing Cholangitis Harald Hofer, Emina Halibasic, Katharina Staufer & Michael Trauner, Chapter 20: Overlap Syndromes Said Al Mamari, Roger Chapman & Kirsten Muri Boberg, Chapter 21: Alcoholic Liver Disease Gyongyi Szabo Chapter 22: Non-Alcoholic Fatty Liver Disease Arun Sanyal & Vaishali Patel Chapter 23: Pediatric Liver Disease Giorgina Mieli-Vergani, Rodrigo Liberal & Diego Vergani Chapter 24: Mechanisms of Acute Liver Failure Christian Trautwein & Alexander Koch Chapter 25: Non-Immune Mediated Drug Induced Hepatotoxicity Christian Strassburg Chapter 26: Immune-Mediated Drug Induced Liver Injury Einar S. Bjornsson & Guruprasad Aithal Chapter 27: The Immunopathogenesis of Cirrhosis Bin Gao, Scott L. Friedman & Wajahat Z. Mehal Chapter 28: Graft vs. Host Disease John Vierling & Ali Raza Chapter 29: Immune-mediated liver disease in the transplantated liver Palak Jitendrakumar Trivedi, Ka-Kit Li & James Neuberger, Chapter 30: The future of liver immunology M. Eric Gershwin, John Vierling & Michael Manns

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall.  In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases --  primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others.  This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients.  Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases.  This volume will again be a must-read for clinicians at all levels, investigators andstudents.

Thoroughly revised, updated and a comprehensively leading title in the field Covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and non-alcoholic fatty liver diseases, as well as transplantation issues Developed by an international panel of leading experts

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