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Lipids in Health and Disease

Quinn, Peter Wang Xiaoyuan
Innbundet / 2008 / Engelsk

Produktdetaljer

ISBN
9781402088308
Publisert
2008-09-25
Utgiver
Vendor
Springer-Verlag New York Inc.
Høyde
234 mm
Bredde
156 mm
Aldersnivå
Research, P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet

Redaktør
Quinn, Peter
Wang Xiaoyuan

Lipids in Health and Disease

Quinn, Peter Wang Xiaoyuan
Innbundet / 2008 / Engelsk
Quinn, Peter Wang Xiaoyuan
Innbundet / 2008 / Engelsk
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Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
Les mer
The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume.
Fatty Acids.- Transcriptional Regulation of Hepatic Fatty Acid Metabolism.- Modulation of Protein Function by Isoketals and Levuglandins.- Signalling Pathways Controlling Fatty Acid Desaturation.- Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System.- Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids.- Eicosanoids in Tumor Progression and Metastasis.- Fatty Acid Synthase Activity in Tumor Cells.- Phospholipids.- Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders.- Altered Lipid Metabolism in Brain Injury and Disorders.- Lysophospholipid Activation of G Protein-Coupled Receptors.- Phospholipid-Mediated Signaling and Heart Disease.- The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases.- Mediation of Apoptosis by Oxidized Phospholipids.- Sphingolipids.- Regulation of lipid metabolism by sphingolipids.- Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis.- Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics.- Glycosphingolipid Disorders of the Brain.- Role of Neutral Sphingomyelinases in Aging and Inflammation.- Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets.- Ceramide-Enriched Membrane Domains in Infectious Biology and Development.- Lipidomics.- MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids.- Lipidomics in diagnosis of lipidoses.
Les mer
The lipids represent targets for cell regulation Their role in signaling processes increasingly recognized Their role in cell-cell recognition and social behaviour of cells is identified Potential therapeutic targets for gene transfection
Les mer
GPSR Compliance The European Union's (EU) General Product Safety Regulation (GPSR) is a set of rules that requires consumer products to be safe and our obligations to ensure this. If you have any concerns about our products you can contact us on ProductSafety@springernature.com. In case Publisher is established outside the EU, the EU authorized representative is: Springer Nature Customer Service Center GmbH Europaplatz 3 69115 Heidelberg, Germany ProductSafety@springernature.com
Les mer

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Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
Les mer
The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume.
Fatty Acids.- Transcriptional Regulation of Hepatic Fatty Acid Metabolism.- Modulation of Protein Function by Isoketals and Levuglandins.- Signalling Pathways Controlling Fatty Acid Desaturation.- Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System.- Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids.- Eicosanoids in Tumor Progression and Metastasis.- Fatty Acid Synthase Activity in Tumor Cells.- Phospholipids.- Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders.- Altered Lipid Metabolism in Brain Injury and Disorders.- Lysophospholipid Activation of G Protein-Coupled Receptors.- Phospholipid-Mediated Signaling and Heart Disease.- The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases.- Mediation of Apoptosis by Oxidized Phospholipids.- Sphingolipids.- Regulation of lipid metabolism by sphingolipids.- Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis.- Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics.- Glycosphingolipid Disorders of the Brain.- Role of Neutral Sphingomyelinases in Aging and Inflammation.- Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets.- Ceramide-Enriched Membrane Domains in Infectious Biology and Development.- Lipidomics.- MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids.- Lipidomics in diagnosis of lipidoses.
Les mer
The lipids represent targets for cell regulation Their role in signaling processes increasingly recognized Their role in cell-cell recognition and social behaviour of cells is identified Potential therapeutic targets for gene transfection
Les mer
GPSR Compliance The European Union's (EU) General Product Safety Regulation (GPSR) is a set of rules that requires consumer products to be safe and our obligations to ensure this. If you have any concerns about our products you can contact us on ProductSafety@springernature.com. In case Publisher is established outside the EU, the EU authorized representative is: Springer Nature Customer Service Center GmbH Europaplatz 3 69115 Heidelberg, Germany ProductSafety@springernature.com
Les mer

Produktdetaljer

ISBN
9781402088308
Publisert
2008-09-25
Utgiver
Vendor
Springer-Verlag New York Inc.
Høyde
234 mm
Bredde
156 mm
Aldersnivå
Research, P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet

Redaktør
Quinn, Peter
Wang Xiaoyuan

Relaterte produkter