Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.
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This book provides an insightful and useful forum to help understand the relevance of hydrogen peroxide generation in human biology. This book is for readers with an interest in the generation of ROS, but without expertise in chemistry, and experts in oxidative stress, but without detailed understanding of the biologically relevant setting.
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Introduction: What is ROS? The generation of hydrogen peroxide in biology. The neutrophil NADPH oxidase. The NOX enzymes. Mitochondrial oxidant production. Hydrogen peroxide generation in high oxygen conditions. Hydrogen peroxide generation in inflammation. Proteins that metabolise and utilise hydrogen peroxide. Hemoglobin. Myeloperoxidase. Eosinophil peroxidise. Catalase. Glutathione peroxidise. The biological consequences of hydrogen peroxide production. Hydrogen peroxide in inflammation. Protein peroxides. The generation of hypohalous acids. Hydrogen peroxide mediated signalling. Antioxidant protection against hydrogen peroxide – thiol chemistry. The Glutathione system. Thioredoxin system. Peroxiredoxins
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Produktdetaljer
ISBN
9781498776158
Publisert
2017-10-16
Utgiver
Vendor
CRC Press Inc
Vekt
1050 gr
Høyde
234 mm
Bredde
156 mm
Aldersnivå
U, G, 05, 01
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
482