1. Definition and terminology 2. Epidemiology 3. Genetics 4. Morphology 5. Associated cardiac and non-cardiac malformations 6. Fetal diagnosis 7. Ethical implications of fetal diagnosis 8. Fetal interventions 9. Fetal brain damages 10. Post-natal diagnosis 11. Pathophysiology 12. Neonatal care 13. Required diagnostic information for decision-making 14. Anesthesia 15. Interventional cardiology procedures 16. Surgical procedures, including neonatal palliations, hybrid procedures, bidirectional Glenn and variations, Fontan completion, biventricular repair 17. Peri-operative management 18. Interstage monitoring 19. Required post-operative diagnostic information 20. Fontan failure, with Fontan take-down and conversion, and mechanical circulatory support 21. Transplantation, including heart, heart and lung, heart and liver 22. Exercise 23. Pregnancy 24. Adolescents and adults without Fontan completion 25. Psychological aspects 26. Role of the families 27. Neurodevelopmental outcomes 28. Management in low-income countries 29. Comparative medicine 30. Future studies

Summarizes all information currently available on single ventricle Includes all age-related aspects, from the fetal diagnosis through adolescent life Covers all factors, including genetics, ethnicity, race, gender, associated cardiac and non-cardiac malformations, diagnostic and interventional procedures, natural history, and outcomes of the available treatments available for all medical professionals caring for these children Lays the groundwork for potential future research