This book covers two decades of the author’s studies about fetal-originated diseases. It contains researches from the aspects of multiple inducing factors of fetal-originated diseases, such as prenatal xenobiotic exposure, nutritional deficiency and other adverse environment during pregnancy; the establishment of animal models of diseases such as a variety of metabolic and neuropsychiatric diseases; the mechanisms for developmental toxicity and susceptibility to multiple diseases, such as glucocorticoid programming; the identification of series of biomarkers of developmental toxicity; and early warning and prevention and treatment strategies of fetal-originated diseases. The content of this book is systematic and complete. It can provide useful information for researchers of related areas.