Addresses the biological effects of the large number of compounds that have been recognized as endocrine disrupters. This book presents the relevant fundamentals of the endocrine systems of animals and humans, the toxicology, developmental toxicology, ecology, and risk assessment methods, and lays out the state of understanding for the field.

Part I. Vertebrate Chemical Regulation 1.: David O. Norris and James A. Carr: Introduction to Endocrinology 2.: Miles Orchinik and Catherine Propper: Hormone Action on Receptors 3.: James A. Carr and David O. Norris: The Hypothalamus-Pituitary Axis 4.: James A. Carr and David O. Norris: The Thyroid Gland 5.: James A. Carr and David O. Norris: The Adrenal Glands 6.: James A. Carr and David O. Norris: The Gonads Part II. Toxicology and Risk Assessment 7.: Richard L. Dickerson and Ernest E. Smith: Introduction to the Science of Toxicology 8.: Kenneth R. Dixon and Clyde F. Martin: Probablistic Risk Assessment 9.: Lynn Frame and Richard L. Dickerson: Fish and Wildlife as Sentinels of Environmental Contamination Part III. Representative EDCs in Animals 10.: Mary K. Walker: Polychlorinated Dibenzo-p-Dioxins: Potential Mechanisms and Risk as Endocrine Disruptors 11.: John P. Giesy, K. Kannan, Alan L. Blankenship, Paul D. Jones, and J.L. Newsted: Toxicology of PDBs and Related Compounds 12.: Louis J. Guillette, Jr., Stefan A.E. Kools, Mark P. Gunderson, and Dieldrich S. Bermudez: DDT and Its Analogues: New Insights into Their Endocrine-Disrupting Effects on Wildlife 13.: Alice Hontela and Alexandra Lacroix: Heavy Metals 14.: Werner Kloas: Effects of Alkyphenolic Compounds on Wildlife 15.: Alan M. Vajda and David O. Norris: Endocrine-Active Phytochemicals: Environmental Signaling Context and Mechanisms 16.: Timothy S. Gross and R. Heath Rauschenberger: Triazines Appendices