Closing Evidence Gaps in Clinical Prevention, a new consensus study report from the National Academies of Sciences, Engineering, and Medicine's Board on Population Health and Public Health Practice, evaluates evidence gaps in clinical prevention recommendations described by the United States Preventive Services Task Force and other clinical practice guideline developers and presents a taxonomy of these evidence gaps for future use. This report aims to improve the coordination of efforts to describe and communicate priority evidence gaps among funders and researchers. It also proposes new opportunities for collaboration among researchers, funders, and guideline developers to accelerate research that could close evidence gaps. The authoring committee has also developed an interactive graphic that can be used as a workflow diagram for implementing the taxonomy. This workflow walks users through reviewing evidence, characterizing evidence gaps using relevant taxonomies, and developing a research agenda. Click here to view and engage with the interactive graphic. Table of ContentsFront MatterSummary1 Introduction2 Clinical Practice Guidelines and the U.S. Preventive Services Task Force3 Clinical Prevention Research Enterprise4 Taxonomy and Workflow5 RecommendationsAppendix A: Topics with "I Statements" from the U.S. Preventive Services Task ForceAppendix B: Research MethodsAppendix C: Public Meeting AgendasAppendix D: Committee Member and Staff BiographiesAppendix E: U.S. Preventive Services Task Force's Reports to CongressAppendix F: U.S. Preventive Service Task Force Research Needs Statements from I Statements Issued Between 2017 and 2021