This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy.

Annexinopathies.- Calpains and Human Disease.- Gelsolin and Diseases.- Guanylate Cyclase-Activating Proteins and Retina Disease.- Pathologies Involving the S100 Proteins and Rage.- The Calcium-Sensing Receptor: Physiology, Pathophysiology and Car-Based Therapeutics.- Physiological Roles Of The Ca2+/Cam-Dependent Protein kinase Cascade In Health and Disease.- Calcium Channelopathies: Voltage-Gated Calcium Channels.- Trp Channels In Disease.- Diseases associated with altered ryanodine receptor activity.- Inositol 1,4,5-tripshosphate receptor, calcium signalling and huntington’s disease.- Serca pumps and human diseases.- The plasma membrane calcium ATPase and disease.- Diseases involving the Golgi calcium pump.- Calcium signalling and cancer cell growth.- Calcium Misregulation and the Pathogenesis of Muscular Dystrophy.- Calcium and Cell Death.- Calcium and Cell Death: The Mitochondrial Connection.- Role of Calcium in the Pathogenesis of Alzheimer’s Disease and Transgenic Models.- Calcium and Cardiomyopathies.- Calcium Signalling and Calcium Transport in Bone Disease.

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