In this issue of _Clinics in Chest Medicine_, guest editors Drs. Eddy Fan, Shannon M. Fernando, and Sarina Sahetya bring their considerable expertise to the topic of ACUTE RESPIRATORY DISTRESS SYNDROME. Top experts discuss environmental risk factors for ARDS; genetic and molecular risk factors for ARDS; biomarkers of ARDS; cellular mechanisms of lung injury; ARDS phenotypes and precision medicine; and more. * Contains 19 RELEVANT, PRACTICE-ORIENTED TOPICS including prone positioning; steroids and immunomodulatory therapy for ARDS; early rehabilitation in ARDS; extracorporeal support for ARDS; long-term outcomes/PICS after ARDS; ARDS in the immunocompromised patient; future directions; and more. * Provides in-depth CLINICAL REVIEWS ON ACUTE RESPIRATORY DISTRESS SYNDROME, offering actionable insights for clinical practice. * Presents the LATEST INFORMATION ON THIS TIMELY, FOCUSED TOPIC under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.