1 Endogenous Substances Which Can Affect Gastrointestinal Motility.- General Introduction.- References.- 2a Peptides: Gastrointestinal Hormones.- Gastrin.- Cholecystokinin.- Secretin.- Gastric Inhibitory Polypeptide.- 2b Peptides: Candidate Hormones.- Substance P.- Motilin.- Neurotensin.- Bombesin.- 2c Peptides: Pancreatic Hormones.- Glucagon.- Insulin.- Pancreatic Polypeptide.- 2d Peptides: Other Hormones.- Vasopressin.- Calcitonin.- Coherin.- Thyrotropin-Releasing Hormone.- 2e Peptides: Locally Active Peptides (“Vasoactive Peptides”).- Angiotensin.- Bradykinin.- 3 Amines: Histamine.- A. Introduction.- B. Activity on the Lower Esophageal Sphincter.- C. Action on the Stomach.- D. Gastric Emptying.- E. Action on the Intestine.- F. H2-Receptors.- G. Conclusions.- References.- 4 Acidic Lipids: Prostaglandins.- A. Introduction.- B. Occurrence, Formation, Release, and Degradation of Prostanoids.- C. Actions of Prostanoids on the Tone and Reactivity of Isolated Gastrointestinal Muscle.- D. Prostanoids and Gastrointestinal Nerves.- E. Prostanoid Antagonists and Different Types of Prostanoid Receptors.- F. Prostanoids and Peristalsis In Vitro.- G. Prostanoids and Motility In Vivo.- H. Prostanoids as Factors in Disordered Gastrointestinal Motility.- J. Beneficial Effects of Prostanoids in Disorders of Gastrointestinal Motility.- K. Conclusions.- References.- 5 Pharmacology of Adrenergic, Cholinergic, and Drugs Acting on Other Receptors in Gastrointestinal Muscle.- A. General Principles.- B. Drugs Acting on Adrenoceptors.- C. Cholinergic Receptors in the Gastrointestinal Tract.- D. Morphine and Drugs Acting on Opiate Receptors.- E. Laxatives and Constipating Agents.- F. Direct and Indirect Actions.- G. Serotonin Receptors and Antagonists.- H. Histamine Receptors andAntagonists.- J. Projections for the Future.- References.- 6 Hydrophilic Colloids in Colonic Motility.- A. Introduction.- B. The Nature of Stool Bulk and How it is Provided.- C. Actions of Fibre and of Operations on the Colon Muscle in Diverticular Disease.- D. Actions in Other Colonic Diseases.- E. Clinical Application of Fibre and Hydrophilic Colloid Additives.- References.- 7 Motility and Pressure Studies in Clinical Practice.- A. The Esophagus.- B. The Stomach.- C. The Small Intestine.- D. The Large Bowel.- E. Conclusions.- References.

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