Why is epistemic fallibilism a viable topic for Christian thought and cultural engagement today? Religious fundamentalists and scientific positivists tend to deal with reality in terms of “knockdown” arguments, and such binary approaches to lived reality have helped to underwrite the belligerence and polarization that mark this age of the social media echo chamber. For those who want to take both religion and science seriously, epistemic fallibilism offers a possible moderating stance that claims neither too much nor too little for either endeavor, nor forces a decision for one side over and against the other. This book uses this epistemological approach to fallibilism as a positive resource for conversations that arise at the intersection of philosophy, theology, and religion. The essays explore a range of openings into the interstices of these often siloed fields, with the aim of overcoming some of the impasses separating diverse ways of knowing.