This volume constitutes the refereed proceedings of the Confederated International Conferences: Cooperative Information Systems, CoopIS 2016, Ontologies, Databases, and Applications of Semantics, ODBASE 2016, and Cloud and Trusted Computing, C&TC, held as part of OTM 2016 in October 2016 in Rhodes, Greece.The 45 full papers presented together with 16 short papers were carefully reviewed and selected from 133 submissions. The OTM program every year covers data and Web semantics, distributed objects, Web services, databases, information systems, enterprise workow and collaboration, ubiquity, interoperability, mobility,grid and high-performance computing.