The European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, ECML PKDD 2010, was held in Barcelona, September 20-24, 2010, consolidating the long junction between the European Conference on Machine Learning (of which the ?rst instance as European wo- shop dates back to 1986) and Principles and Practice of Knowledge Discovery in Data Bases (of which the ?rst instance dates back to 1997). Since the two conferences were ?rst collocated in 2001, both machine learning and data m- ing communities have realized how each discipline bene?ts from the advances, and participates to de?ning the challenges, of the sister discipline. Accordingly, a single ECML PKDD Steering Committee gathering senior members of both communities was appointed in 2008. In 2010, as in previous years, ECML PKDD lasted from Monday to F- day. It involved six plenary invited talks, by Christos Faloutsos, Jiawei Han, Hod Lipson, Leslie Pack Kaelbling, Tomaso Poggio, and Jur .. gen Schmidhuber, respectively. Monday and Friday were devoted to workshops and tutorials, or- nized and selected by Colin de la Higuera and Gemma Garriga.Continuing from ECML PKDD 2009, an industrial session managed by Taneli Mielikainen and Hugo Zaragoza welcomed distinguished speakers from the ML and DM ind- try: Rakesh Agrawal, Mayank Bawa, Ignasi Belda, Michael Berthold, Jos'eLuis Fl' orez,ThoreGraepel,andAlejandroJaimes. Theconferencealsofeaturedad- coverychallenge,organizedbyAndr' asBenczur ' ,CarlosCastillo,Zolt' anGyon .. gyi, and Julien Masan' es.