This book constitutes the refereed proceedings of the 16th International Symposium on Methodologies for Intelligent Systems, ISMIS 2006. The book presents 81 revised papers together with 3 invited papers. Topical sections include active media human-computer interaction, computational intelligence, intelligent agent technology, intelligent information retrieval, intelligent information systems, knowledge representation and integration, knowledge discovery and data mining, logic for AI and logic programming, machine learning, text mining, and Web intelligence.