This book highlights cutting-edge research in the field of network science, offering scientists, researchers, students, and practitioners a unique update on the latest advances in theory and a multitude of applications. It presents the peer-reviewed proceedings of the XI International Conference on Complex Networks and their Applications (COMPLEX NETWORKS 2022). The carefully selected papers cover a wide range of theoretical topics such as network models and measures; community structure, network dynamics; diffusion, epidemics, and spreading processes; resilience and control as well as all the main network applications, including social and political networks; networks in finance and economics; biological and neuroscience networks and technological networks.